Visual versus semiquantitative analysis of F-18 fluorodeoxyglucose-positron emission tomography brain images in patients with dementia

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dc.authoridKamel, Walaa/0000-0002-3363-0370
dc.authoridSarikaya, Ismet/0000-0002-1087-580X
dc.authorwosidKamel, Walaa/AAP-8573-2020
dc.authorwosidSarikaya, Ismet/G-7881-2015
dc.contributor.authorSarikaya, Ismet
dc.contributor.authorKamel, Walaa A.
dc.contributor.authorAteyah, Khattab Khaled
dc.contributor.authorBin Essa, Nooraessa
dc.contributor.authorAlTailji, Samira
dc.contributor.authorSarikaya, Ali
dc.date.accessioned2024-06-12T10:55:08Z
dc.date.available2024-06-12T10:55:08Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractVarious studies have reported to the superiority of semiquantitative (SQ) analysis over visual analysis in detecting metabolic changes in the brain. In this study, we aimed to determine the limitations of SQ analysis programs and the current status of F-18 fluorodeoxyglucose (FDG)-positron emission tomography (PET) scan in dementia. F-18 FDG-PET/computed tomography (CT) brain images of 39 patients with a history of dementia were analyzed both visually and semiquantitatively. Using the visually markedly abnormal F-18 FDG-PET images as standard, we wanted to test the accuracy of two commercially available SQ analysis programs. SQ analysis results were classified as matching, partially matching and nonmatching with visually markedly abnormal studies. On visual analysis, F-18 FDG-PET showed marked regional hypometabolism in 19 patients, mild abnormalities in 8 and was normal in 12 patients. SQ analysis-1 results matched with visual analysis in 8 patients (42.1%) and partially matched in 11. SQ analysis-2 findings matched with visual analysis in 11 patients (57.8%) and partially matched in 7 and did not match in 1. Marked regional hypometabolism was either on the left side of the brain or was more significant on the left than the right in 63% of patients. Preservation of metabolism in sensorimotor cortex was seen in various dementia subtypes. Reviewing images in color scale and maximum intensity projection (MIP) image was helpful in demonstrating and displaying regional abnormalities, respectively. SQ analysis provides less accurate results as compared to visual analysis by experts. Due to suboptimal image registration and selection of brain areas, SQ analysis provides inaccurate results, particularly in small areas and areas in close proximity. Image registration and selection of areas with SQ programs should be checked carefully before reporting the results.en_US
dc.identifier.doi10.4103/wjnm.WJNM_53_18
dc.identifier.endpage89en_US
dc.identifier.issn1450-1147
dc.identifier.issn1607-3312
dc.identifier.issue1en_US
dc.identifier.pmid33850493en_US
dc.identifier.startpage82en_US
dc.identifier.urihttps://doi.org/10.4103/wjnm.WJNM_53_18
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19297
dc.identifier.volume20en_US
dc.identifier.wosWOS:000672647100011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofWorld Journal Of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrain Imagingen_US
dc.subjectDementiaen_US
dc.subjectF-18 Fluorodeoxyglucose-Positron Emission Tomographyen_US
dc.subjectSemiquantitative Analysisen_US
dc.subjectVisual Analysisen_US
dc.subjectAlzheimers-Diseaseen_US
dc.subjectFrontotemporal Dementiaen_US
dc.subjectDifferential-Diagnosisen_US
dc.subjectAutomated-Analysisen_US
dc.subjectLewy Bodiesen_US
dc.subjectFdg Peten_US
dc.subjectHypoperfusionen_US
dc.subjectF-18-Fdg-Peten_US
dc.subjectMulticenteren_US
dc.subjectImpairmenten_US
dc.titleVisual versus semiquantitative analysis of F-18 fluorodeoxyglucose-positron emission tomography brain images in patients with dementiaen_US
dc.typeArticleen_US

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