SIGNIFICANCE OF INSULIN-LIKE GROWTH FACTOR-I EXPRESSION IN BLADDER TUMORS

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dc.authorwosidKaplan, Mustafa/D-4977-2014
dc.contributor.authorOzbakir, Fikret
dc.contributor.authorKaplan, Mustafa
dc.contributor.authorUsta, Ufuk
dc.contributor.authorAktoz, Tevfik
dc.contributor.authorAtakan, Irfan Huseyin
dc.contributor.authorInci, Osman
dc.date.accessioned2024-06-12T10:54:48Z
dc.date.available2024-06-12T10:54:48Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: Insulin-like growth factor-I is a mitogenic peptide which overexpression involved in the aberrant cell proliferation and malign transformation. It was thought that it can show the malign behavior of bladder tumors. Our aim in this study is to investigate the relationship between insulin like growth factor expression and tumor grade, stage and recurrence in patients with bladder tumor. Materials and Methods: 53 patients that performed transurethral tumor resection or radical cystectomy between 2002 and 2007 were included in this study. Insulin like growth factor-I staining was determined by immunohistochemically from the bladder tumor tissue. Then we investigated the relationship between insulin like growth factor expression in bladder tumor tissue and tumor grade, stage, and recurrence. Results: The mean age was 64.4+/-11.9, 32 patients have low grade, 21 have high grade; 35 have superficial, 18 have muscle invasive tumor. Of 35 patients with superficial tumors, 25 patients have regular follow-up and the mean follow-up duration was 21.9+/-8.1 month. There was no significant difference in insulin-like growth factor-I staining degree between low grade and high grade tumors. Insulin-like growth factor-I staining degree was same in both superficial and muscle invasive tumors. We found no relationship between recurrence and insulin-like growth factor-I staining degree. Conclusion: We found no association between tumor grade, stage, and recurrence and insulin-like growth factor-I staining degree in bladder tumors.en_US
dc.identifier.endpage14en_US
dc.identifier.issn2149-3057
dc.identifier.issue1en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19187
dc.identifier.volume34en_US
dc.identifier.wosWOS:000420482500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal Of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBladder Tumoren_US
dc.subjectInsulin-Like Growth Factor-Ien_US
dc.subjectRecurrenceen_US
dc.subjectProstate-Cancer Risken_US
dc.subjectPreoperative Plasma-Levelsen_US
dc.subjectFactor-Binding Protein-3en_US
dc.subjectBreast-Canceren_US
dc.subjectSerum-Levelsen_US
dc.subjectIgf-Ien_US
dc.subjectRecurrenceen_US
dc.subjectAssociationen_US
dc.subjectPredictorsen_US
dc.subjectSurvivalen_US
dc.titleSIGNIFICANCE OF INSULIN-LIKE GROWTH FACTOR-I EXPRESSION IN BLADDER TUMORSen_US
dc.typeArticleen_US

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