Evaluation of morphine effect on tumour angiogenesis in mouse breast tumour model, EATC

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dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.contributor.authorUstun, Funda
dc.contributor.authorDurmus-Altun, Gulay
dc.contributor.authorAltaner, Semsi
dc.contributor.authorTuncbilek, Nermin
dc.contributor.authorUzal, Cem
dc.contributor.authorBerkarda, Sakir
dc.date.accessioned2024-06-12T11:08:43Z
dc.date.available2024-06-12T11:08:43Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBreast cancer is the leading cause of death among women, and morphine is used to relieve the pain of patients with cancer. The data on the effects of morphine on tumour growth and angiogenesis are contradictory. We determined in mouse breast cancer model whether analgesic doses of morphine would affect tumour angiogenesis, and then the correlation between microvessel density (MVD), Doppler sonography (DS) and Tc-99m-Tetrofosmin (TF) uptake. Ehrlich ascites tumour cell xenografts, Pgp-negative tumour were divided into two groups: (a) Morphine sulphate [0.714 mg/kg/day (equivalent to 50 mg per day for a 70 kg human)], (b) no-morphine. For the determination of angiogenesis in mice tumour tissue, TF scintigraphy, microvessel density and DS were done. MVD was significantly different between groups (49.4 +/- 1.8 vs. 41.8 +/- 1.9, morphine and no-morphine groups, respectively, P < 0.001). A strong correlation was found between late uptakes of mass at scintigraphy and degree of angiogenesis in histopathologic examination (r = 0.52, P < 0.01). There was statistically significant inverse correlation between degree of angiogenesis in histopathologic examination and washout ratio of TF (r = 0.40, P < 0.05). The higher values for angiogenesis are related to higher TF reuptake. There was no statistically significant correlation between DS and TF. A strong correlation was found between MVD and grade of DS (r = 0.51, P < 0.01). Our preclinical mice study indicates that morphine at clinically relevant doses stimulates angiogenesis, and angiogenesis triggered of morphine is demonstrated with MVD and DS, but not TF. However, uptake and washout of TF are compared with immunohistochemically assessed morphine-stimulated angiogenesis in tumour tissue.en_US
dc.description.sponsorshipTrakya University (TUBAP) [615]en_US
dc.description.sponsorshipThis study was supported by Trakya University Research Fund (TUBAP) no. 615.en_US
dc.identifier.doi10.1007/s12032-010-9573-5
dc.identifier.endpage1272en_US
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue4en_US
dc.identifier.pmid20567944en_US
dc.identifier.scopus2-s2.0-80052365486en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1264en_US
dc.identifier.urihttps://doi.org/10.1007/s12032-010-9573-5
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22539
dc.identifier.volume28en_US
dc.identifier.wosWOS:000297256400049en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofMedical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMorphineen_US
dc.subjectAngiogenesisen_US
dc.subjectTc-99m Tetrofosminen_US
dc.subjectMicrovessel Densityen_US
dc.subjectDoppler Sonographyen_US
dc.subjectP-Glycoprotein Expressionen_US
dc.subjectCancer Cell-Lineen_US
dc.subjectOpioids Induceen_US
dc.subjectGrowthen_US
dc.subjectReceptoren_US
dc.subjectTechnetium-99m-Tetrofosminen_US
dc.subjectTc-99m-Mibien_US
dc.subjectInvolvementen_US
dc.subjectTetrofosminen_US
dc.subjectMetastasisen_US
dc.titleEvaluation of morphine effect on tumour angiogenesis in mouse breast tumour model, EATCen_US
dc.typeArticleen_US

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