The Preoperative use of gabapentin, dexamethasone, and their combination in varicocele surgery

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dc.contributor.authorKoc, Serhat
dc.contributor.authorMemis, Dilek
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:19:58Z
dc.date.available2024-06-12T11:19:58Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBACKGROUND: We investigated the effects of gabapentin and dexamethasone given together or separately 1 h before the start of surgery on laryngoscopy, tracheal intubation, intraoperative hemodynamics, opioid consumption, and postoperative pain in patients undergoing varicocele operations. METHODS: Patients were randomly divided into four double-blind groups: group C (control, n = 20) received placebo, group G (gabapentin, n = 20) received 800 mg gabapentin, group D (dexamethasone, n = 20) received 8 mg dexamethasone, group GD (gabapentin plus dexamethasone) received both 800 mg gabapentin and 8 mg dexamethasone IV 1 h before the start of surgery. Standard induction and maintenance of anesthesia were accomplished and continued by propofol and remifentanil infusion. Heart rate and arterial blood pressure were recorded before induction and after intubation. Intraoperative total remifentanil consumption was recorded. Hemodynamic variables and visual analog scale were recorded RESULTS: Hemodynamics at 1, 3, 5, and 10 min after tracheal intubation, total remifentanil consumption during surgery, postoperative visual analog scale scores at 30 min, 1, 2, 4, 6, and 12 h, and postoperative nausea and vomiting were found to be significantly lower in group GD than in group G and group D (P < 0.05 for both), and substantially lower when compared with group C (P < 0.001). All values in group C were also higher than in groups G and D (P < 0.05). CONCLUSION: Gabapentin and dexamethasone administered together an hour before varicocele surgery results in less laryngeal and tracheal intubation response, improves postoperative analgesia, and prevents postoperative nausea and vomiting better than individual administration of each drug.en_US
dc.identifier.doi10.1213/01.ane.0000278869.00918.b7
dc.identifier.endpage1142en_US
dc.identifier.issn0003-2999
dc.identifier.issue4en_US
dc.identifier.pmid17898401en_US
dc.identifier.scopus2-s2.0-34748905974en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1137en_US
dc.identifier.urihttps://doi.org/10.1213/01.ane.0000278869.00918.b7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25396
dc.identifier.volume105en_US
dc.identifier.wosWOS:000249678500038en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnesthesia And Analgesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSmooth-Muscle Cellsen_US
dc.subjectPostoperative Nauseaen_US
dc.subjectLaparoscopic Cholecystectomyen_US
dc.subjectSynaptic-Transmissionen_US
dc.subjectTracheal Intubationen_US
dc.subjectCalcium Currentsen_US
dc.subjectChannel Subuniten_US
dc.subjectUp-Regulationen_US
dc.subjectPainen_US
dc.subjectResponsesen_US
dc.titleThe Preoperative use of gabapentin, dexamethasone, and their combination in varicocele surgeryen_US
dc.typeArticleen_US

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