The effects of apomorphine on paracetamol-induced hepatotoxicity in rats

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridŞehitoğlu, M Hilal/0000-0003-4436-9160
dc.authoridOztopuz, Rahime Ozlem/0000-0002-1373-6311
dc.authoridbayir, yasin/0000-0003-3562-6727
dc.authoridYayla, Muhammed/0000-0002-0659-3084
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidŞehitoğlu, M Hilal/V-3841-2019
dc.authorwosidOztopuz, Rahime Ozlem/AFK-7508-2022
dc.authorwosidbayir, yasin/B-3645-2016
dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorYayla, Muhammet
dc.contributor.authorKiraz, Asli
dc.contributor.authorOztopuz, Rahime Ozlem
dc.contributor.authorBayir, Yasin
dc.contributor.authorKaraca, Turan
dc.contributor.authorKhalid, Sumbul
dc.date.accessioned2024-06-12T10:52:20Z
dc.date.available2024-06-12T10:52:20Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIt is becoming progressively more understandable that overdose of paracetamol in both humans and animals causes severe hepatotoxicity. Apomorphine is known as a neuroprotective agent. Due to the protective effect, apomorphine had been tested in experimental studies on different models. Findings obtained through series of expriments suggested that apomorphine may also be useful in liver toxicity. The aim of this study is to investigate the relationship among the hepatoprotective mechanism of apomorphine and to determine the possible role of apomorphine on paracetamol-induced hepatotoxicity in rats. 30 Sprague Dawley rats (adult male) were distributed into 5 groups. Group 1 was the control group and did not receive any medication. Group 2 received only paracetamol 2 g/kg by intragastric gavage to induce hepatotoxicity. Groups 3 and 4 were given apomorphine 1 mg/kg and 2 mg/kg by intraperitoneal injection, respectively. Groups 3 and 4 were given 2g/kg of Paracetamol. In Group 5, rats were treated with 2 mg/kg of apomorphine. Drug-treated rats were given food for the next 24 h until they were sacrified. Moreover, we also performed AST, ALT measurements in serum, MDA and SOD levels in liver tissues and histopathological analysis of the liver in all groups. Apomorphine had positive effects on both liver enzymes, oxidative stress markers and histopathological results in paracetamol-induced hepatotoxicity. Additionally, apomorphine at 2 mg/kg dose was significantly more protective as compared to 1 mg/kg as evidenced by the histopathological examination results. It was thought that apomorphine was found hepatoprotective on paracetamol-induced hepatotoxicity, especially at higher doses such as 2 mg/kg.en_US
dc.identifier.doi10.14715/cmb/2017.63.12.10
dc.identifier.endpage44en_US
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue12en_US
dc.identifier.pmid29307340en_US
dc.identifier.scopus2-s2.0-85039993534en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage40en_US
dc.identifier.urihttps://doi.org/10.14715/cmb/2017.63.12.10
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18676
dc.identifier.volume63en_US
dc.identifier.wosWOS:000419272800010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherC M B Assocen_US
dc.relation.ispartofCellular And Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApomorphineen_US
dc.subjectHepatotoxicityen_US
dc.subjectParacetamolen_US
dc.subjectRaten_US
dc.subjectAcute Liver-Failureen_US
dc.subjectAcetaminophen Hepatotoxicityen_US
dc.subjectSuperoxide-Dismutaseen_US
dc.subjectAntioxidanten_US
dc.subjectToxicityen_US
dc.subjectBiomarkersen_US
dc.subjectIschemiaen_US
dc.subjectStressen_US
dc.subjectInjuryen_US
dc.subjectBrainen_US
dc.titleThe effects of apomorphine on paracetamol-induced hepatotoxicity in ratsen_US
dc.typeArticleen_US

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