The analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgery

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dc.contributor.authorTuran, A
dc.contributor.authorMemis, D
dc.contributor.authorKaramanlioglu, B
dc.contributor.authorYagiz, R
dc.contributor.authorPamukçu, Z
dc.contributor.authorYavuz, E
dc.date.accessioned2024-06-12T11:19:46Z
dc.date.available2024-06-12T11:19:46Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe investigated the efficacy and safety of gabapentin in rhinoplasty or endoscopic sinus surgery patients. Patients received either oral placebo or gabapentin 1200 mg 1 h before surgery. After standard premedication, 25 patients in each group received propofol, fentanyl, and local anesthesia at the operative site. Sedation was maintained by a continuous infusion of propofol adjusted according to the Ramsay scale. Sedation and pain scores were obtained at 5, 15, 30, 45, and 60 min during surgery and 30 min and 2,4,6,8, 12, 16, 20, and 24 h after the procedure. Diclofenac 75 mg IM was administered as a rescue analgesic. Postoperative pain scores and intraoperative pain scores at 45 and 60 min were significantly lower in the gabapentin group. Fentanyl (122 +/- 40 mug versus 148 +/- 42 mug; P < 0.05) and diclofenac (33 +/- 53 mg versus 111 +/- 92 mg; P < 0.001) consumption was smaller and the time to first analgesic request (18 +/- 9 h versus 9 +/- 7 h; P < 0.001) was longer in the gabapentin group. A more frequent incidence of dizziness was found in the gabapentin (versus placebo) group (24% versus 4%, respectively). We conclude that gabapentin provided a significant analgesic benefit for intraoperative and postoperative pain relief in patients undergoing ambulatory rhinoplasty or endoscopic sinus surgery; however, dizziness may be a handicap for ambulatory use.en_US
dc.identifier.endpage378en_US
dc.identifier.issn0003-2999
dc.identifier.issue2en_US
dc.identifier.pmid15271709en_US
dc.identifier.scopus2-s2.0-3242787135en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage375en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25333
dc.identifier.volume99en_US
dc.identifier.wosWOS:000222897100013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnesthesia And Analgesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRandomized Controlled-Trialen_US
dc.subjectPostoperative Painen_US
dc.subjectRaten_US
dc.subjectHyperalgesiaen_US
dc.subjectManagementen_US
dc.subjectCanceren_US
dc.titleThe analgesic effects of gabapentin in monitored anesthesia care for ear-nose-throat surgeryen_US
dc.typeArticleen_US

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