Assessing oral glucose and intravenous insulin loading protocol in18F-fluorodeoxyglucose positron emission tomography cardiac viability studies

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dc.authoridSarikaya, Ismet/0000-0002-1087-580X
dc.authorwosidSarikaya, Ismet/G-7881-2015
dc.contributor.authorSarikaya, Ismet
dc.contributor.authorSharma, Prem N.
dc.contributor.authorSarikaya, Ali
dc.contributor.authorElgazzar, Abdelhamid H.
dc.date.accessioned2024-06-12T10:50:11Z
dc.date.available2024-06-12T10:50:11Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOral glucose and intravenous insulin (G/I) loading protocols are commonly used in18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) cardiac viability studies. Although the amount of insulin to be given per blood glucose range has been well described in guidelines, the amount of glucose to be given is not detailed well. In this retrospective study, we aimed to assess if certain parameters, particularly the amount of glucose and insulin given, may affect18F-FDG uptake in the hibernating myocardium and also determine the problems with this protocol.18F-FDG PET cardiac viability study with G/I loading protocols was performed in 49 patients. Fasting blood glucose (FBG), amount of glucose given, blood glucose level after glucose load, amount of insulin given, and blood glucose level at the time of18F-FDG injection were recorded. Statistical analysis was performed to determine if there is any difference in the above values in PET viable and PET nonviable groups and also in subgroups assessing18F-FDG uptake also in normal myocardium. For G/I loading, we used our local protocol in 43 patients, and other protocols in six.18F-FDG PET showed viability in 31 patients, and it was negative for viability in 18. In 22 patients, mainly in PET viable group, there was varying degree of reduced18F-FDG uptake in normal myocardium. There was no significant difference in FBG, amount of glucose given, blood glucose level after glucose load, amount of insulin given, and blood glucose level at the time of18F-FDG injection in PET viable and PET nonviable groups and also in subgroups. The problems with G/I loading protocol included deciding on the amounts of glucose and insulin given, maximum amount of insulin to be given, handling diabetics, optimal time to measure blood glucose after insulin administration, and interpretation of findings in cases with diffusely reduced18F-FDG uptake. Further improvements in current guidelines are necessary to obtain images in optimal conditions for accurate results.en_US
dc.identifier.doi10.4103/wjnm.WJNM_58_18
dc.identifier.endpage7en_US
dc.identifier.issn1450-1147
dc.identifier.issn1607-3312
dc.identifier.issue1en_US
dc.identifier.pmid32190015en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.4103/wjnm.WJNM_58_18
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17893
dc.identifier.volume19en_US
dc.identifier.wosWOS:000672646200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofWorld Journal Of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject18F-Fluorodeoxyglucose Positron Emission Tomographyen_US
dc.subjectMyocardial Viabilityen_US
dc.subjectOral Glucose And Intravenous Insulin Loadingen_US
dc.subjectCoronary-Artery-Diseaseen_US
dc.subjectEuglycemic Hyperinsulinemic Clampen_US
dc.subjectDependent Diabetes-Mellitusen_US
dc.subjectNormal Myocardial-Perfusionen_US
dc.subjectF-18 Fluorodeoxyglucoseen_US
dc.subjectPeten_US
dc.subjectMetabolismen_US
dc.titleAssessing oral glucose and intravenous insulin loading protocol in18F-fluorodeoxyglucose positron emission tomography cardiac viability studiesen_US
dc.typeArticleen_US

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