Use of mometasone furoate aqueous nasal spray in the treatment of rhinitis medicamentosa: An experimental study

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dc.authoridYALCIN, OMER TARIK/0000-0001-5626-1881
dc.authoridUZUN, CEM/0000-0003-3233-7049
dc.authoridTas, Abdullah/0000-0002-5689-087X
dc.authorwosidYALCIN, OMER TARIK/B-4744-2018
dc.authorwosidUZUN, CEM/K-3307-2012
dc.contributor.authorTas, A
dc.contributor.authorYagiz, R
dc.contributor.authorYalcin, O
dc.contributor.authorUzun, C
dc.contributor.authorHuseyinova, G
dc.contributor.authorAdali, MK
dc.contributor.authorKarasalihoglu, AR
dc.date.accessioned2024-06-12T11:17:43Z
dc.date.available2024-06-12T11:17:43Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: We aimed to investigate, histopathologic changes in the nasal mucosa of guinea pig's after prolonged administration of oxymetazoline and the development of rhinitis medicamentosa, and the efficacy of mometasone furoate aqueous nasal spray and saline in reversing the ultrastructural changes attributable to rhinitis medicamentosa. METHODS: In the study, 24 male guinea pigs (500 to 600 gr) were used. Oxymetazolin (0.05%) was sprayed into the nasal cavities of the guinea pigs 3 times daily for 8 weeks. At the end of this period, 6 guinea pigs were killed and examined to make sure that the animals had developed rhinitis medicamentosa. The remaining guinea pigs were randomly divided into 3 groups. In the first group, one spray-puff of 0.05% mometasone furoate aqueous nasal spray (50 mu g) was applied twice daily for 14 days. In the second group, saline solution (0.9% NaCl) was applied twice daily for 14 days. No treatment was performed in the third group. At the end of the treatment period, nasal mucosal changes were evaluated by light microscopy and electron microscopy. RESULTS: After oxymetazolin application for 8 weeks, the main histologic changes were edema, congestion, proliferation of subepithelial glands, and squamous cell metaplasia. After topical mometasone furoate aqueous spray application for 2 weeks, the edema fluid was found to diminish markedly. In the saline and no treatment groups, edema and congestion continued. In these groups of guinea pigs, fibrosis has been seen in the nasal mucosa. CONCLUSION. We found that mometasone furoate nasal spray was effective against experimentally induced rhinitis medicamentosa in guinea pigs. Mometasone furoate nasal spray may have value in the treatment of patients with rhinitis medicamentosa.en_US
dc.identifier.doi10.1016/j.otohns.2005.01.010
dc.identifier.endpage612en_US
dc.identifier.issn0194-5998
dc.identifier.issue4en_US
dc.identifier.pmid15806055en_US
dc.identifier.scopus2-s2.0-16244389939en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage608en_US
dc.identifier.urihttps://doi.org/10.1016/j.otohns.2005.01.010
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24802
dc.identifier.volume132en_US
dc.identifier.wosWOS:000228111900018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby, Incen_US
dc.relation.ispartofOtolaryngology-Head And Neck Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzalkonium Chlorideen_US
dc.subjectFluticasone Propionateen_US
dc.subjectMucosaen_US
dc.titleUse of mometasone furoate aqueous nasal spray in the treatment of rhinitis medicamentosa: An experimental studyen_US
dc.typeArticleen_US

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