The effect of aprotinin on extraneural scarring in peripheral nerve surgery

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dc.authoridSencer, Altay/0000-0001-9925-5422
dc.authoridSimsek, Osman/0000-0002-8716-5187
dc.authorwosidSencer, Altay/AAD-8002-2020
dc.authorwosidSimsek, Osman/D-4906-2012
dc.contributor.authorGörgülü, A
dc.contributor.authorImer, M
dc.contributor.authorSimsek, O
dc.contributor.authorSencer, A
dc.contributor.authorKutlu, K
dc.contributor.authorCobanoglu, S
dc.date.accessioned2024-06-12T10:52:27Z
dc.date.available2024-06-12T10:52:27Z
dc.date.issued1998
dc.departmentTrakya Üniversitesien_US
dc.description.abstractExtraneural scarring is one of the factors negatively influencing the result of peripheral nerve surgery. Many organic materials have been used to prevent fibrosis. The effect of aprotinin on peripheral nerve scarring in rats was investigated in this study. Three types of surgical intervention were carried out; namely external neurolysis (I), abrasive injury (II), and anastomosis (III). The coded samples which consisted of pure collagen fibers soaked with aprotinin or phosphate-buffered saline were applied around the left sciatic nerves of rats whereas only sham operations were performed on the right sciatic nerves. Animals were sacrificed after 4 or 6 weeks. Neurological examination, gross evaluation of extraneural fibrosis, and histological study were undertaken. The results have demonstrated that aprotinin is a promising agent in the prevention of extraneural scarring.en_US
dc.identifier.doi10.1007/s007010050254
dc.identifier.endpage1307en_US
dc.identifier.issn0001-6268
dc.identifier.issue12en_US
dc.identifier.pmid9932133en_US
dc.identifier.scopus2-s2.0-0345196541en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1303en_US
dc.identifier.urihttps://doi.org/10.1007/s007010050254
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18704
dc.identifier.volume140en_US
dc.identifier.wosWOS:000077839600036en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Wienen_US
dc.relation.ispartofActa Neurochirurgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAprotininen_US
dc.subjectPeripheral Nerveen_US
dc.subjectScar Inhibitionen_US
dc.subjectTraumaen_US
dc.subjectRegenerationen_US
dc.titleThe effect of aprotinin on extraneural scarring in peripheral nerve surgeryen_US
dc.typeArticleen_US

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