Ace gene polymorphisms are ineffective on contrast induced nephropathy

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dc.authoridTAYLAN, GOKAY/0000-0002-7015-4537
dc.authorwosidTAYLAN, GOKAY/HJZ-4693-2023
dc.contributor.authorKilic, Ilhan
dc.contributor.authorPalabiyik, Orkide
dc.contributor.authorTaylan, Gokay
dc.contributor.authorSipahi, Tammam
dc.contributor.authorUstundag, Sedat
dc.date.accessioned2024-06-12T10:58:25Z
dc.date.available2024-06-12T10:58:25Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: The renin-angiotensin system regulates the haemodynamics. ACE gene polymorphisms are known to influence serum angiotensin converting enzyme level. Contrast nephropathy develops after exposure to intravascular contrast media that influence vascular hemodynamics. ACE gene polymorpisms may have an enhancing role in contrast media related renal injury. The aim of the study: The aim of this study was to investigate the impact of ACE insertion/deletion (I/D) polymorphism in contrast-induced nephropathy (CIN) development. Methods: 194 patients with chronic kidney disease that were administered iodinated contrast media were examined. Patients were monitored for at least 7 days for CIN development after parenteral contrast exposure. Control and patient groups were divided in terms of CIN development status. Polymerase chain reaction was performed for the genotyping of the ACE gene polymorphism from DNAs that were isolated from peripheral blood of the patients. Results: 83 patients with CIN (34 women, 49 men) and 111 control patients without CIN (43 women, 68 men) were enrolled. Gender was not statistically different between the two groups (p = 0.75). The average age of the CIN group (71) was greater than that of the control group (68). No association was detected between ACE gene polymorphism (II, ID AND DD genotypes) and CIN in both patients and controls. Conclusion: ACE gene polymorphisms does not influence contrast induced nephropathy development.en_US
dc.identifier.doi10.1016/j.mgene.2021.100992
dc.identifier.issn2214-5400
dc.identifier.scopus2-s2.0-85118592128en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.1016/j.mgene.2021.100992
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20062
dc.identifier.volume31en_US
dc.identifier.wosWOS:000720342700009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMeta Geneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectContrast Nephropathyen_US
dc.subjectRenal Failureen_US
dc.subjectGene Polymorphismen_US
dc.subjectPolymerase Chain Reactionen_US
dc.subjectAngiotensin-Converting-Enzymeen_US
dc.subjectInsertion-Deletion Polymorphismen_US
dc.subjectCoronary-Artery-Diseaseen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectKidney-Diseaseen_US
dc.subjectAssociationen_US
dc.subjectProgressionen_US
dc.subjectGenotypeen_US
dc.subjectLinkageen_US
dc.subjectRisken_US
dc.titleAce gene polymorphisms are ineffective on contrast induced nephropathyen_US
dc.typeArticleen_US

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