Antiproliferative and antiapoptotic effect of thymoquinone on cancer cells in vitro

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dc.authoridDemirci, Fatih/0000-0003-1497-3017
dc.authoridGoger, Gamze/0000-0003-2978-5385
dc.authoridkabadere, selda/0000-0002-9589-0063
dc.authorwosidDemirci, Fatih/A-8295-2008
dc.authorwosidGöger, Gamze/ABB-8437-2020
dc.authorwosidkus, Gokhan/V-3405-2017
dc.authorwosidGoger, Gamze/JCE-6911-2023
dc.authorwosidözkurt, mete/ACM-2771-2022
dc.contributor.authorKus, G.
dc.contributor.authorOzkurt, M.
dc.contributor.authorKabadere, S.
dc.contributor.authorErkasap, N.
dc.contributor.authorGoger, G.
dc.contributor.authorDemirci, F.
dc.date.accessioned2024-06-12T11:16:20Z
dc.date.available2024-06-12T11:16:20Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVES: Nigella sativa oil and thymoquinone were comparatively tested in vitro for their effects on human cancer cell lines (glioma, T98; prostate, LnCaP) as well as mouse embryonic fi broblast cell lines (3T3), and for the induction of apoptosis. METHODS: Individual cell lines were treated with thymoquinone and N. sativa oil for 24 and 48 hr. Survival rate with MTT, apoptosis with fl ow cytometry and caspase-9 mRNA enzyme levels with RT-PCR were determined in vitro. RESULTS: Application of respective concentrations of N. sativa oil (excluding 100 mu g/mL for 48 hr) did not change the number of tested cell lines, however, treatment with thymoquinone reduced the number of all cells signifi cantly. Thymoquinone also exerted its apoptosis inducing effect through the activation of caspase-9. CONCLUSION: Differing with the type of cancer cells, thymoquinone posseses a strong contentration and time dependent survival reducing effect on cancer cells via apoptosisen_US
dc.identifier.doi10.4149/BLL_2018_059
dc.identifier.endpage316en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue5en_US
dc.identifier.pmid29749248en_US
dc.identifier.scopus2-s2.0-85047224225en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage312en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2018_059
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24285
dc.identifier.volume119en_US
dc.identifier.wosWOS:000432448800012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThymoquinoneen_US
dc.subjectIn Vitroen_US
dc.subjectApoptosisen_US
dc.subjectAntiproliferativeen_US
dc.subjectAnticanceren_US
dc.subjectSativa Seed Oilen_US
dc.subjectNigella-Sativaen_US
dc.subjectApoptosisen_US
dc.subjectProliferationen_US
dc.subjectActivationen_US
dc.subjectStressen_US
dc.subjectGrowthen_US
dc.subjectModelen_US
dc.subjectLineen_US
dc.titleAntiproliferative and antiapoptotic effect of thymoquinone on cancer cells in vitroen_US
dc.typeArticleen_US

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