Evaluation of the Fas/FasL signaling pathway in diabetic rat testis

Basit Öğe Kaydı
dc.authoridBayram, Sinasi/0000-0003-4785-4751
dc.authorwosidBayram, Sinasi/AAK-7568-2021
dc.contributor.authorBayram, S.
dc.contributor.authorKizilay, G.
dc.contributor.authorTopcu-Tarladacalisir, Y.
dc.date.accessioned2024-06-12T10:59:25Z
dc.date.available2024-06-12T10:59:25Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe investigated the role of the Fas/Fas ligand (FasL) signaling pathway in diabetic male infertility. Male rats were divided into two groups: a control group and a streptozotocin induced diabetic group. Thirty days after induction of diabetes, samples of testes were harvested and fixed in 10% formalin for light microscopy. Germ cell apoptosis was determined using the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate in situ nick end-labeling (TUNEL) and immunostaining of caspase 8 and active caspase 3. We also investigated the expressions of Fas and FasL using immunohistochemistry. Streptozotocin-induced diabetes caused severe histopathological damage and increased apoptotic tubule and apoptotic cell indices, caspase 8 and caspase 3 expressions, and Fas and FasL-immunopositive cells in the rat testes. We suggest that the Fas/FasL signaling pathway may play a role in male infertility caused by diabetes.en_US
dc.description.sponsorshipTrakya University Scientific Research Committee, Edirne, Turkey [2013/124]en_US
dc.description.sponsorshipOur study was supported by a grant from the Trakya University Scientific Research Committee (Project number: 2013/124), Edirne, Turkey.en_US
dc.identifier.doi10.3109/10520295.2015.1129556
dc.identifier.endpage211en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3en_US
dc.identifier.pmid26960002en_US
dc.identifier.scopus2-s2.0-84961212883en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage204en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2015.1129556
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20444
dc.identifier.volume91en_US
dc.identifier.wosWOS:000372898400006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectTestisen_US
dc.subjectRaten_US
dc.subjectCaspaseen_US
dc.subjectCaspase 8en_US
dc.subjectFaslen_US
dc.subjectImmunohistochemistryen_US
dc.subjectFasen_US
dc.subject3en_US
dc.subjectGerm-Cell Apoptosisen_US
dc.subjectFas Systemen_US
dc.subjectUp-Regulationen_US
dc.subjectInvolvementen_US
dc.subjectActivationen_US
dc.subjectExpressionen_US
dc.subjectIncreasesen_US
dc.subjectMechanismen_US
dc.subjectEthanolen_US
dc.subjectDamageen_US
dc.titleEvaluation of the Fas/FasL signaling pathway in diabetic rat testisen_US
dc.typeArticleen_US

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