Epigenetic Alterations in Hematologic Malignancies

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dc.authorscopusid56429434500
dc.contributor.authorAtli E.I.
dc.date.accessioned2024-06-12T10:24:46Z
dc.date.available2024-06-12T10:24:46Z
dc.date.issued2023
dc.description.abstractEpigenetic control is necessary for tissue homeostasis, which is preserved through the self-renewal and differentiation of somatic stem cells, as well as for development. Leukemia stem cells and self-renewing hematopoietic stem cells are both maintained by epigenetic regulators, according to mounting evidence. In hematologic malignancies, recent genome-wide comprehensive investigations have discovered mutations in genes that regulate epigenetic processes, including genes whose products change DNA and histones. Both cell-intrinsic and cell-extrinsic regulators, such as transcription factors, signal transduction pathways, and niche factors, affect hematopoietic stem cells. However, little is known about the process through which epigenetic regulators work in conjunction with these elements to maintain blood homeostasis. With an emphasis on the function of DNA-methylation modulators in hematopoietic cells and their offspring, we review current discoveries in the epigenetic control of hematopoiesis in this chapter. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.en_US
dc.identifier.doi10.1007/978-3-031-42365-9_11
dc.identifier.endpage378en_US
dc.identifier.issn2191-2262
dc.identifier.scopus2-s2.0-85179322986en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage363en_US
dc.identifier.urihttps://doi.org/10.1007/978-3-031-42365-9_11
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16009
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofEpigenetics and Human Healthen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDecitabine; Dna Methylation; Hdac Inhibitors; Ten-Eleven-Translocationen_US
dc.subjectDna; Dna Methyltransferase; Dna Methyltransferase Inhibitor; Enzyme; Histone Deacetylase; Histone Deacetylase Inhibitor; Ketoglutarate; Oxoacid; Ten Eleven Translocation Enzyme; Unclassified Drug; Untranslated Rna; Dna Methylation; Enzyme Inhibition; Epigenetics; Hematologic Malignancy; Hematopoiesis; Histone Modification; Human; Metabolism; Nonhuman; Protein Acetylationen_US
dc.titleEpigenetic Alterations in Hematologic Malignanciesen_US
dc.typeBook Chapteren_US

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