Protective effect of Urtica dioica on liver damage induced by biliary obstruction in rats

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dc.authoridIbis, Cem/0000-0002-5602-375X;
dc.authorwosidIbis, Cem/AAE-3388-2020
dc.authorwosidOguz, Serhat/HKE-2793-2023
dc.contributor.authorOguz, Serhat
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErboga, Mustafa
dc.contributor.authorIbis, Cem
dc.date.accessioned2024-06-12T11:16:59Z
dc.date.available2024-06-12T11:16:59Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the possible protective effects of Urtica dioica (UD) against liver damage in the common bile duct-ligated rats. A total of 24 male Sprague Dawley rats were divided into three groups, namely, control, bile duct ligation (BDL) and BDL+received UD groups, containing eight animals in each group. The rats in UD-treated groups were given UD oils (2ml/kg) once a day intraperitoneally for 2weeks starting 3days prior to BDL operation. The change demonstrating the bile duct proliferation and fibrosis in expanded portal tracts includes the extension of proliferated bile ducts into the lobules; inflammatory cell infiltration into the widened portal areas were observed in BDL group. Treatment of BDL with UD attenuated alterations in liver histology. The -smooth muscle actin, cytokeratin-positive ductular proliferation and the activity of terminal deoxynucleotidyl transferase dUTP nick end labeling in the BDL were observed to be reduced with the UD treatment. The data indicate that UD attenuates BDL-induced cholestatic liver injury, bile duct proliferation and fibrosis.en_US
dc.identifier.doi10.1177/0748233712445045
dc.identifier.endpage845en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue9en_US
dc.identifier.pmid22585933en_US
dc.identifier.scopus2-s2.0-84885094660en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage838en_US
dc.identifier.urihttps://doi.org/10.1177/0748233712445045
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24530
dc.identifier.volume29en_US
dc.identifier.wosWOS:000329489600010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology And Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUrtica Dioicaen_US
dc.subjectImmunohistochemistryen_US
dc.subjectTUNELen_US
dc.subjectLiveren_US
dc.subjectBile Duct Ligationen_US
dc.subjectHepatic-Fibrosisen_US
dc.subjectCellsen_US
dc.subjectExpressionen_US
dc.subjectCirrhosisen_US
dc.subjectInjuryen_US
dc.titleProtective effect of Urtica dioica on liver damage induced by biliary obstruction in ratsen_US
dc.typeArticleen_US

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