Lack of effect of ceftriaxone, a GLT-1 transporter activator, on spatial memory in mice

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorKaraman, Ipek
dc.contributor.authorKizilay-Ozfidan, Gulnur
dc.contributor.authorKaradag, C. Hakan
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T10:55:59Z
dc.date.available2024-06-12T10:55:59Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description6th European Congress of Pharmacology -- JUL 17-20, 2012 -- Granada, SPAINen_US
dc.description.abstractIn the central nervous system, glutamate appears to be the principal excitatory amino acid neurotransmitter. Recent findings show that beta-lactam antibiotics, by stimulating glutamate transporter (GLT-1) expression, offer neuroprotection. The purpose of our study is to observe the effect of ceftriaxone, a beta-lactam antibiotic, on spatial memory in mice. Male Balb-c mice, weighing 20-25 g, were trained in Morris water maze (n = 12 for each group) task. Animals were given 4 trials per day for 7 consecutive days to locate a hidden platform (acquisition phase). On the eighth day, the platform is removed and the animals were swum for one session of 60 s (retention phase). Learning and memory functions of the animals were evaluated based on-their performances in these tests. Ceftriaxone was given for 9 days at different doses (50, 100, and 200 mg/kg, i.p.); additionally, its acute effect was evaluated in one group (200 mg/kg, i.p.). Our immunohistochemistry findings indicate that ceftriaxone increases GLT-1 expression in CA1, CA3 and DG regions of hippocampus, especially with the dose of 200 mg/kg. Evaluation of the acquisition parameters, such as time to reach platform, distance moved, and mean distance to platform indicates that chronic ceftriaxone has no effect on learning curves of the animals. When retention phase parameters (e.g. time to reach target quadrant swim duration in target quadrant, and mean distance to platform area) are evaluated, it was found that both chronic and acute ceftriaxone did not affect memory at any dose used. In contrast to the contribution of GLT-1 expression to various central nervous system diseases, such as chronic pain, amyotrophic lateral sclerosis, Parkinson's disease and seizures, our findings suggest that ceftriaxone has no effect on spatial memory function in mice. (C) 2013 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipEPHARen_US
dc.identifier.doi10.1016/j.pbb.2013.04.013
dc.identifier.endpage65en_US
dc.identifier.issn0091-3057
dc.identifier.pmid23628489en_US
dc.identifier.scopus2-s2.0-84877820169en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage61en_US
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2013.04.013
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19628
dc.identifier.volume108en_US
dc.identifier.wosWOS:000321232800007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPharmacology Biochemistry And Behavioren_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCeftriaxoneen_US
dc.subjectGlutamateen_US
dc.subjectGLT-1en_US
dc.subjectSpatial Memoryen_US
dc.subjectBeta-Lactam Antibioticsen_US
dc.subjectHippocampal-Neuronsen_US
dc.subjectGlutamate Uptakeen_US
dc.subjectRat-Brainen_US
dc.subjectExpressionen_US
dc.subjectToleranceen_US
dc.subjectMorphineen_US
dc.subjectExcitotoxicityen_US
dc.subjectDependenceen_US
dc.subjectTerminalsen_US
dc.titleLack of effect of ceftriaxone, a GLT-1 transporter activator, on spatial memory in miceen_US
dc.typeConference Objecten_US

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