Effects of Bupivacaine Versus Levobupivacaine on Pulmonary Function in Patients With Chronic Obstructive Pulmonary Disease Undergoing Urologic Surgery: A Randomized, Double-Blind, Controlled Trial

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dc.authoridŞenol, Mehmet Güney/0000-0001-6397-9293
dc.authoridColak, Alkin/0000-0001-9103-4844
dc.authorwosidŞenol, Mehmet Güney/L-9182-2015
dc.authorwosidColak, Alkin/R-8739-2017
dc.contributor.authorSahin, Sevtap Hekimoglu
dc.contributor.authorInal, Mehmet
dc.contributor.authorAlagol, Aysin
dc.contributor.authorColak, Alkin
dc.contributor.authorArar, Cavidan
dc.contributor.authorBasmergen, Tughan
dc.contributor.authorGunday, Isil
dc.date.accessioned2024-06-12T10:55:26Z
dc.date.available2024-06-12T10:55:26Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBACKGROUND: There are limited data to determine the impact of subarachnoid blockade with local anesthetics on perioperative pulmonary function. The effects of local anesthetics used in spinal anesthesia are very important in terms of respiratory function in patients with chronic obstructive pulmonary disease (COPD). OBJECTIVE: The aim of this study was to evaluate the effects of bupivacaine versus levobupivacaine on pulmonary function in patients with COPD undergoing urologic surgery. METHODS: Patients were randomized into 2 groups: group B (n = 25) received 3 mL of hyperbaric 0.5% bupivacaine; group L (n = 25) received 3 mL of isobaric 0.5% levobupivacaine. Both agents were administered intrathecally. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow rate (PEER), vital capacity (VC), and FEV1/FVC ratio were measured using spirometry 10 and 30 minutes after spinal anesthesia and 30 minutes after completion of the operation. An arterial blood gas test was performed before and after spinal anesthesia. RESULTS: Fifty male patients aged 40 to 80 years completed the study. There were no differences in the results of preoperative and postoperative FVC, FEV1, PEFR, VC, FEV1/FVC ratio, and arterial blood gas between the bupivacaine (n = 25) and levobupivacaine (n = 25) groups. However, patients who took bupivacaine showed a significant decrease in intraoperative PEFR at 30 minutes compared with baseline, a result not seen in patients who took levobupivacaine (P = 0.036 and P = 0.282, respectively). CONCLUSIONS: In 50 patients with moderate COPD undergoing urologic surgery, hyperbaric bupivacaine caused a decrease in intraoperative PEFR compared with baseline because of higher level block; however, the effects of hyperbaric bupivacaine and isobaric levobupivacaine on pulmonary function in these patients showed equally effective potencies for spinal anesthesia. (Curr Ther Res Clin Exp. 2011; 72:164-172) (C) 2011 Elsevier HS Journals, Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.curtheres.2011.06.003
dc.identifier.endpage172en_US
dc.identifier.issn0011-393X
dc.identifier.issn1879-0313
dc.identifier.issue4en_US
dc.identifier.pmid24648586en_US
dc.identifier.scopus2-s2.0-80051593188en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage164en_US
dc.identifier.urihttps://doi.org/10.1016/j.curtheres.2011.06.003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19410
dc.identifier.volume72en_US
dc.identifier.wosWOS:000294576000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical And Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBupivacaineen_US
dc.subjectChronic Obstructive Pulmonary Diseaseen_US
dc.subjectLevobupivacaineen_US
dc.subjectRespiratory Function Testsen_US
dc.subjectSpinal-Anesthesiaen_US
dc.subjectRacemic Bupivacaineen_US
dc.subjectCesarean-Sectionen_US
dc.subjectBaricityen_US
dc.titleEffects of Bupivacaine Versus Levobupivacaine on Pulmonary Function in Patients With Chronic Obstructive Pulmonary Disease Undergoing Urologic Surgery: A Randomized, Double-Blind, Controlled Trialen_US
dc.typeArticleen_US

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