The Effect of Nitric Oxide Synthase Inhibitors on the Development of Analgesic Tolerance to Dipyrone in Mice

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridYILMAZ, Ibrahim/0000-0003-2003-6337
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidYILMAZ, Ibrahim/H-6199-2019
dc.contributor.authorYilmaz, Ibrahim
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T10:51:36Z
dc.date.available2024-06-12T10:51:36Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractRecent investigations have shown that, similarly to opioids, tolerance develops to the analgesic effects of nonsteroidal anti-inflammatory drugs (NSAIDs). Nitric oxide has been shown to play an important role in opioid-induced analgesic tolerance; we, therefore, planned to determine if nitric oxide also plays role in the analgesic tolerance to dipyrone, a NSAID. Using the hot-plate test in mice, an analgesic tolerance developed to dipyrone with its 150 and 300 mg/kg intraperitoneal doses after 7 days; no tolerance was observed with its dose of 600 mg/kg. Neither 7-nitroindazole (50 mg/kg, i.p.), a neuronal NOS inhibitor, nor aminoguanidine (30 mg/kg, i.p.), an inducible NOS inhibitor, had any effect on dipyrone-induced analgesic tolerance with doses, which also had no analgesic effect when used alone. Our results show that nitric oxide does not play role in the analgesic tolerance to dipyrone; however, further experiments are required to delineate the mechanisms and to take preventive measures against this problem, which will possibly limit the use of NSAIDs.en_US
dc.identifier.doi10.1080/00207450902776192
dc.identifier.endpage764en_US
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.issue6en_US
dc.identifier.pmid19326282en_US
dc.identifier.scopus2-s2.0-65649133565en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage755en_US
dc.identifier.urihttps://doi.org/10.1080/00207450902776192
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18406
dc.identifier.volume119en_US
dc.identifier.wosWOS:000264641500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnalgesiaen_US
dc.subjectDipyroneen_US
dc.subjectNitric Oxideen_US
dc.subjectNsaidsen_US
dc.subjectToleranceen_US
dc.subjectOpioid Toleranceen_US
dc.subjectMorphine-Toleranceen_US
dc.subjectNeuropathic Painen_US
dc.subjectPhysical-Dependenceen_US
dc.subjectAbstinence Syndromeen_US
dc.subjectNervous-Systemen_US
dc.subjectL-Arginineen_US
dc.subjectRatsen_US
dc.subjectAntinociceptionen_US
dc.subjectPerspectivesen_US
dc.titleThe Effect of Nitric Oxide Synthase Inhibitors on the Development of Analgesic Tolerance to Dipyrone in Miceen_US
dc.typeArticleen_US

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