Association of FAS-670A/G and FASL-843C/T Gene Polymorphisms on Allograft Nephropathy in Pediatric Renal Transplant Patients

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dc.contributor.authorErtan, Pelin
dc.contributor.authorMir, Sevgi
dc.contributor.authorOzkayin, Nese
dc.contributor.authorBerdeli, Afig
dc.date.accessioned2024-06-12T11:13:36Z
dc.date.available2024-06-12T11:13:36Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: FAS and FASL polymorphisms are suggested to play an important role in tubulitis that is a major component of acute rejection. The aim of this study was to investigate the role of FAS-670A/G and FASL-843C/T gene polymorphisms on allograft nephropathy in pediatric renal transplant patients Methods: Fifty three patients (22 males 31 females) aged 2 to 20 years (mean 12.3 +/- 0.6) who had renal transplantation and fifty healthy control subjects (25 males 25 females) were enrolled in the study. Pearson's Chi Square test was used for the statistical analysis. Survival rates were estimated with the Kaplan Meier method. Age, sex, chronic renal failure etiology, treatment modality and duration and donor type were recorded. FAS-670A/G and FASL-843C/T gene polymorphisms were compared between renal transplant patients and normal healthy population as well as between renal transplant patients with and without acute rejection. Findings: FAS-670A/G genotypes or alleles were not significantly different between control and transplant patients and among transplant patients with and without acute rejection (P>0.05 for all). FASL-843C/T genotypes and alleles were not different between transplantation and control groups (P>0.05 for all). However, FASL-843C/T alleles were significantly different between patients with and without AR (P=0.02). The percentages of C allele were higher in children with acute rejection (68.8% vs 44.6%). Conclusion: FASL gene polymorphisms may play a major role in acute rejection while FAS polymorphisms have not been found to be different between patients with and without acute, renal graft rejection.en_US
dc.identifier.endpage450en_US
dc.identifier.issn2008-2142
dc.identifier.issue4en_US
dc.identifier.pmid23056744en_US
dc.identifier.startpage442en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23594
dc.identifier.volume20en_US
dc.identifier.wosWOS:000286175900009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIranian Scientific Society Medical Entomologyen_US
dc.relation.ispartofIranian Journal Of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRenal Transplantationen_US
dc.subjectFAS Liganden_US
dc.subjectGenetic Polymorphismen_US
dc.subjectGenotypeen_US
dc.subjectTnfrsf6 Fas Geneen_US
dc.subjectPromoter Regionen_US
dc.subjectAcute Rejectionen_US
dc.subjectMediated Apoptosisen_US
dc.subjectMessenger-Rnaen_US
dc.subjectLiganden_US
dc.subjectExpressionen_US
dc.subjectDiagnosisen_US
dc.subjectIdentificationen_US
dc.subjectLymphocytesen_US
dc.titleAssociation of FAS-670A/G and FASL-843C/T Gene Polymorphisms on Allograft Nephropathy in Pediatric Renal Transplant Patientsen_US
dc.typeArticleen_US

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