Investigation of the roles of IL-18 (-607 C/A) and IL-18 (-137 G/C) gene variations in bladder cancer development: case-control study

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dc.authoridÇevik, Gökhan/0000-0001-5221-5132
dc.authoridAlkanli, Nevra/0000-0002-3745-8838
dc.authorwosidAlkanli, Nevra/D-4400-2019
dc.authorwosidÇevik, Gökhan/GZA-3993-2022
dc.contributor.authorAlkanli, Nevra
dc.contributor.authorAy, Arzu
dc.contributor.authorCevik, Gokhan
dc.date.accessioned2024-06-12T10:54:47Z
dc.date.available2024-06-12T10:54:47Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground The purpose of our study is to investigate the roles of IL-18 gene variations in bladder cancer development in Thrace population of Turkey. Methods This study was carried out with 103 bladder cancer patients and 81 healthy controls. Genotype distributions of IL-18 (-137 G/C) and IL-18 (-607 C/A) gene variations were determined using polymerase chain reaction (PCR) method. Results The CC homozygous genotype for IL-18 (-607 C/A) gene variation was significantly higher in patients with bladder cancer compared to healthy controls (OR 0.345, 95% Cl 0.186-0.639, p = 0.001). Besides this, allele frequencies of IL-18 (-137 G/C) and IL-18 (-607 C/A) gene variations in patient with bladder cancer and healthy control groups were significantly different from the Hardy-Weinberg distribution (p < 0.05). For IL-18 (-137 G/C) and IL-18 (-607 C/A) gene variations, significant difference was determined between the bladder cancer patient and healthy control groups in terms of GC-CA (OR 0.381, 95% Cl 0.203-0.714, p = 0.002), GC-CC (OR 2.147, 95% Cl 1.013-4.550, p = 0.043), GG-AA (OR 0.431, 95% Cl 0.365-0.509, p = 0.049), and GG-CC (OR 2.476, 95% Cl 1.177-5.208, p = 0.015) haplotypes. Conclusion In our study, CC genotype of IL-18 (-607 C/A) gene variation was determined as genetic risk factor for bladder cancer development. In bladder cancer patient and healthy control groups, G and C allele frequencies of IL-18 (-137 G/C) gene variation, and C and A allele frequencies of IL-18 (-607 C/A) gene variation were determined significantly different from the Hardy-Weinberg distribution.en_US
dc.identifier.doi10.1007/s00432-021-03808-y
dc.identifier.endpage3637en_US
dc.identifier.issn0171-5216
dc.identifier.issn1432-1335
dc.identifier.issue12en_US
dc.identifier.pmid34550451en_US
dc.identifier.scopus2-s2.0-85115296654en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3627en_US
dc.identifier.urihttps://doi.org/10.1007/s00432-021-03808-y
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19179
dc.identifier.volume147en_US
dc.identifier.wosWOS:000698368600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Cancer Research And Clinical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBladder Canceren_US
dc.subjectIL-18 Geneen_US
dc.subjectIL-18 (-607 Cen_US
dc.subjectA) Gene Variationen_US
dc.subjectIL-18 (-137 Gen_US
dc.subjectC) Gene Variationen_US
dc.subjectPCRen_US
dc.subjectSerum Interleukin-18en_US
dc.subjectPolymorphismsen_US
dc.subjectRisken_US
dc.subjectAssociationen_US
dc.subjectPromoteren_US
dc.subjectSusceptibilityen_US
dc.subjectInflammationen_US
dc.titleInvestigation of the roles of IL-18 (-607 C/A) and IL-18 (-137 G/C) gene variations in bladder cancer development: case-control studyen_US
dc.typeArticleen_US

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