Antidiabetic activity evaluation of Onobrychis species on alloxan-induced diabetic mice

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dc.authoridISCAN, Gülçin SALTAN/0000-0001-6633-0713
dc.authoridAcıkara, Özlem Bahadır/0000-0003-0809-784X
dc.authoridOzbek, hanefi/0000-0002-8084-7855
dc.authoridKirmizi Sonmez, N Ipek/0000-0001-8294-0802
dc.authoridOZBILGIN, Serkan/0000-0002-3945-6756
dc.authorwosidISCAN, Gülçin SALTAN/AAG-8646-2020
dc.authorwosidAcıkara, Özlem Bahadır/AAH-4682-2020
dc.authorwosidOzbek, hanefi/O-3472-2019
dc.authorwosidKirmizi Sonmez, N Ipek/HDM-7962-2022
dc.contributor.authorOzbek, Hanefi
dc.contributor.authorAcikara, Ozlem Bahadir
dc.contributor.authorOz, Burcin Ergene
dc.contributor.authorOzbilgin, Serkan
dc.contributor.authorKirmizir, Neriman Ipek
dc.contributor.authorOzrenk, Bade Cevriye
dc.contributor.authorTekin, Mehmet
dc.date.accessioned2024-06-12T11:09:35Z
dc.date.available2024-06-12T11:09:35Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn the current study, four Onobrychis species, O. albiflora Hub.-Mor., O. argyrea Boiss. subsp. argyrea Boiss., O. galegifolia Boiss., and O. tournefortii (Willd.) Desv. were collected from Anatolia to be evaluated for their antidiabetic activities. Methanol water extracts of the aerial parts were used for experiments. An alloxan-induced diabetic mice test model was used. Phytochemical analysis of the tested extracts was investigated using the HPLC method. The highest activity was observed with treatment of O. albiflora aerial part extract. Significant decrements were detected in the blood glucose levels as follows: 180.83 +/- 47.48 and 252.83 +/- 50.47mg/dL at 100 mg/kg and 200 mg/kg doses of O. albiflora, respectively, when compared to the isotonic saline solution control group, eliciting a blood glucose level of 494.20 +/- 27.32. Among the tested standard compounds, rutin and isoquercetin were detected in the examined species. The highest amount of rutin (1.1981 +/- 0.0017%) and isoquercetin (0.7318 +/- 0.0197%) were found in O. albiflora and O. argyrea subsp. argyrea, respectively. Antidiabetic activities of the tested Onobrychis species seem to indicate a possible correlation with their rutin and isoquercetin contents. Therefore, rutin and isoquercetin may be the antidiabetic compounds that contribute to the antidiabetic activity of the tested Onobrychis species.en_US
dc.identifier.doi10.1590/s2175-97902019000118157
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.scopus2-s2.0-85070005099en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1590/s2175-97902019000118157
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22875
dc.identifier.volume55en_US
dc.identifier.wosWOS:000476635000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Sao Paulo, Conjunto Quimicasen_US
dc.relation.ispartofBrazilian Journal Of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOnobrychisen_US
dc.subjectAntidiabetic Activityen_US
dc.subjectAlloxanen_US
dc.subjectRutinen_US
dc.subjectIsoquercetinen_US
dc.subjectPhytochemical Analysisen_US
dc.subjectAntioxidant Activitiesen_US
dc.subjectPhenolic-Compoundsen_US
dc.subjectPlantsen_US
dc.subjectGlycosidesen_US
dc.subjectRutinen_US
dc.titleAntidiabetic activity evaluation of Onobrychis species on alloxan-induced diabetic miceen_US
dc.typeArticleen_US

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