Preparation of new molecularly imprinted nanosensor for cholic acid determination

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dc.authoridErsoz, Arzu/0000-0002-2726-2065
dc.authorwosidDenizli, Adil/G-5151-2012
dc.contributor.authorGultekin, Aytac
dc.contributor.authorErsoz, Arzu
dc.contributor.authorDenizli, Adil
dc.contributor.authorSay, Ridvan
dc.date.accessioned2024-06-12T11:02:47Z
dc.date.available2024-06-12T11:02:47Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMolecular imprinted polymers (MIPs) as a recognition element for sensors are increasingly of interest and MIP-nanoparticles have started to appear in the literature. In this study, we have proposed a novel thiol ligand-capping method with polymerizable methacryloylamido-cysteine (MAC) attached to gold nanoparticles, reminiscent of a self-assembled monolayer and have reconstructed surface shell by synthetic host polymers based on molecular imprinting method for recognition. In this method, methacryloylamidohistidine-Pt(II) [MAH-Pt(II)] has used as a new metal-chelating monomer via metal coordination-chelation interactions and cholic acid. Nanoshell sensors with templates give a cavity that is selective for cholic acid. The cholic acid can simultaneously chelate to Pt(II) metal ion and fit into the shape-selective cavity. Thus, the interaction between Pt(II) ion and free coordination spheres has an effect on the binding ability of the gold nanoparticles nanosensor. The binding affinity of the cholic acid imprinted nanoparticles has investigated by using the Langmuir and Scatchard methods and determined affinity constant (K-affinity) were found as 1.48 x 10(4) mol L-1 and 6.59 x 10(6) mol L-1, respectively. At the last step of this procedure, cholic acid level in blood serum and urine which belong to healthy people was determined by the prepared Au nanosensor. (C) 2012 Elsevier B.V. All rights reserved,en_US
dc.identifier.doi10.1016/j.snb.2011.12.053
dc.identifier.endpage158en_US
dc.identifier.issn0925-4005
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84856738288en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://doi.org/10.1016/j.snb.2011.12.053
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21396
dc.identifier.volume162en_US
dc.identifier.wosWOS:000301214700023en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofSensors And Actuators B-Chemicalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGold Nanoparticle Sensoren_US
dc.subjectMolecularly Imprinted Polymersen_US
dc.subjectCholic Aciden_US
dc.subjectPhotoluminescenceen_US
dc.subjectPerformance Liquid-Chromatographyen_US
dc.subjectSurface-Plasmon Resonanceen_US
dc.subjectBile-Acidsen_US
dc.subjectUrsodeoxycholic Aciden_US
dc.subjectBiological-Fluidsen_US
dc.subjectHuman Serumen_US
dc.subjectDnaen_US
dc.subjectNanoshellen_US
dc.subjectPolymersen_US
dc.subjectSensoren_US
dc.titlePreparation of new molecularly imprinted nanosensor for cholic acid determinationen_US
dc.typeArticleen_US

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