Adding dexmedetomidine to lidocaine for intravenous regional anesthesia

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dc.contributor.authorMemis, D
dc.contributor.authorTuran, A
dc.contributor.authorKaramanlioglu, B
dc.contributor.authorPamukçu, Z
dc.contributor.authorKurt, I
dc.date.accessioned2024-06-12T11:20:05Z
dc.date.available2024-06-12T11:20:05Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractDexmedetomidine is approximately 8 times more selective toward the alpha-2-adrenoceptors than clonidine. It decreases anesthetic requirements by up to 90% and induces analgesia in patients. We designed this study to evaluate the effect of dexmedetomidine when added to lidocaine in IV regional anesthesia (IVRA). We investigated onset and duration of sensory and motor blocks, the quality of the anesthesia, intraoperative-postoperative hemodynamic variables, and intraoperative-postoperative pain and sedation. Thirty patients undergoing hand surgery were randomly assigned to 2 groups to receive IVRA. They received 40 mL of 0.5% lidocaine and either 1 mL of isotonic saline (group L, n = 15) or 0.5 mug/kg dexmedetomidine (group LD, n = 15). Sensory and motor block onset and recovery times and anesthesia quality were noted. Before and after the tourniquet application at 5, 10, 15, 20, and 40 min, hemodynamic variables, tourniquet pain and sedation, and analgesic use were recorded. After the tourniquet deflation, at 30 min, and 2, 4, 6, 12, and 24 h, hemodynamic variables, pain and sedation values, time to first analgesic requirement, analgesic use, and side effects were noted. Shortened sensory and motor block onset times, prolonged sensory and motor block recovery times, prolonged tolerance for the tourniquet, and improved quality of anesthesia were found in group LD. Visual analog scale scores were significantly less in group LD in the intraoperative period and 30 min, and 2, 4, and 6 h after tourniquet release. Intra-postoperative analgesic requirements were significantly less in group LD. Time to first analgesic requirements was significantly longer in group LD in the postoperative period. We conclude that the addition of 0.5 mug/kg dexmedetomidine to lidocaine for IVRA improves quality of anesthesia and perioperative analgesia without causing side effects.en_US
dc.identifier.endpage840en_US
dc.identifier.issn0003-2999
dc.identifier.issue3en_US
dc.identifier.pmid14980948en_US
dc.identifier.startpage835en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25466
dc.identifier.volume98en_US
dc.identifier.wosWOS:000189250000051en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnesthesia And Analgesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTourniquet Painen_US
dc.subjectHealthy-Volunteersen_US
dc.subjectUpper Extremityen_US
dc.subjectClonidineen_US
dc.subjectPremedicationen_US
dc.subjectMaintenanceen_US
dc.subjectAgonisten_US
dc.subjectSurgeryen_US
dc.titleAdding dexmedetomidine to lidocaine for intravenous regional anesthesiaen_US
dc.typeArticleen_US

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