Two-fold excess of fluoride in the drinking water has no obvious health effects other than dental fluorosis

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dc.authoridOnur, Şirin Güner/0000-0002-6890-3500
dc.authoridmentes, ali/0000-0002-2778-6803
dc.authoridsezgin, batin ilgit/0000-0001-9578-9611
dc.authoridHAZNEDAROGLU, Eda/0000-0003-0792-2465
dc.authoridVieira, Alexandre/0000-0003-3392-6881
dc.authorwosidHaznedaroğlu, Eda/AAA-9039-2019
dc.authorwosidOnur, Şirin Güner/AAL-3712-2021
dc.authorwosidHaznedaroğlu, Eda/U-6139-2019
dc.authorwosidmentes, ali/HJZ-1125-2023
dc.authorwosidsezgin, batin ilgit/HKO-9029-2023
dc.contributor.authorSezgin, Batin Ilgit
dc.contributor.authorOnur, Sirin Guner
dc.contributor.authorMentes, Ali
dc.contributor.authorOkutan, Alev Eda
dc.contributor.authorHaznedaroglu, Eda
dc.contributor.authorVieira, Alexandre Rezende
dc.date.accessioned2024-06-12T11:02:04Z
dc.date.available2024-06-12T11:02:04Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground. There is concern that fluorides in the drinking water is hazardous to health. Methods: We conducted an observational study in the village of Hanliyenice (population 280), Turkey, which has 2.5 times higher than optimal levels of fluoride in the drinking water and evaluated all children 7-13 years of age (N = 30). We collected information on dental decay, fluorosis, daily water consumption and diet, child history and her family history of cancer, cardiovascular risks/diseases, and asthma, and obtained a blood sample for extraction of genomic DNA. We genotyped ten single nucleotide polymorphisms in aquaporins. Results: As expected, a high number of children were dental caries free (19 out of 30) and had fluorosis (25 out of 30). Family history of cancer, cardiovascular events, and asthma was not different from the expected figures based on Turkey. One variant just upstream of AQP5 was associated with being fluorosis free. (G allele of AQP5 rs296763, p = 6.0E(-6)). Conclusions: Exposure to levels of fluoride twice as high than the optimum in the drinking water increases the prevalence of fluorosis, dramatically decreases dental caries, and does not increase the risk of cancer, cardiovascular events, and asthma.en_US
dc.identifier.doi10.1016/j.jtemb.2018.07.004
dc.identifier.endpage222en_US
dc.identifier.issn0946-672X
dc.identifier.pmid30262282en_US
dc.identifier.scopus2-s2.0-85049863811en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage216en_US
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2018.07.004
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21134
dc.identifier.volume50en_US
dc.identifier.wosWOS:000448633900029en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofJournal Of Trace Elements In Medicine And Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFluorosisen_US
dc.subjectCardiovascular Diseaseen_US
dc.subjectCanceren_US
dc.subjectAsthmaen_US
dc.subjectDental Cariesen_US
dc.subjectAquaporinen_US
dc.subjectPolymorphismsen_US
dc.subjectGenesen_US
dc.titleTwo-fold excess of fluoride in the drinking water has no obvious health effects other than dental fluorosisen_US
dc.typeArticleen_US

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