Do the adiponectin and leptin levels in preterm and term breast milk samples relate to infants' short-term growth?

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dc.authoridKocaadam, Betül/0000-0002-9058-4630
dc.authoridKoksal, Eda/0000-0002-7930-9910
dc.authoridKocaadam, Betül/0000-0002-9058-4630
dc.authorwosidKocaadam, Betül/AAE-6850-2019
dc.authorwosidKoksal, Eda/AAW-2900-2021
dc.authorwosidKocaadam, Betül/Y-9145-2018
dc.contributor.authorKocaadam, Betul
dc.contributor.authorKoksal, Eda
dc.contributor.authorOzcan, Kudret Ebru
dc.contributor.authorTurkyilmaz, Canan
dc.date.accessioned2024-06-12T10:50:45Z
dc.date.available2024-06-12T10:50:45Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAdiponectin and leptin are involved in appetite control and body weight regulation. We aimed to evaluate the relationship between breast milk adipokine levels and short-term growth of preterm and term infants. Thirty-one preterm (median=35.3 weeks) and 34 term (median=38.7 weeks) infants were enrolled. Enzyme-linked immunosorbent assay was used to detect adipokines in mature milk. Infant growth was followed during the first 3 months. Although weight gain in the first month was insufficient, positive linear growth was observed in the following months for preterm infants, while term infants had positive steady linear growth. The median level of adipokines was found to be higher in preterm infants (P>0.05). Adiponectin showed significant negative correlations with some anthropometric measurements of term infants. However, in preterm infants, adiponectin was negatively correlated with length increment and positively correlated with body mass index (BMI) increment in the second-third month. In addition, leptin was negatively associated with the head circumference at birth in preterm infants and the triceps skinfold thickness increment in the first-second month term infants (P<0.05). In linear regression models, while gestational age, adiponectin and leptin were not related, maternal age and pre-pregnancy BMI had effects on body weight increment in 0-1 months (P<0.05). In conclusion, adiponectin may affect short-term growth, while leptin has no important effect. It would be beneficial to carry out longitudinal studies to evaluate the effects of these adipokines on the growth of infants.en_US
dc.description.sponsorshipOYPen_US
dc.description.sponsorshipB.K. was supported by a research grant from OYP. OYP is the abbreviation for the Faculty Development Programme (Ogretim Uyesi Yetistirme Programi), established to train academicians.en_US
dc.identifier.doi10.1017/S2040174418000703
dc.identifier.endpage258en_US
dc.identifier.issn2040-1744
dc.identifier.issn2040-1752
dc.identifier.issue2en_US
dc.identifier.pmid30203736en_US
dc.identifier.scopus2-s2.0-85053146948en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage253en_US
dc.identifier.urihttps://doi.org/10.1017/S2040174418000703
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18104
dc.identifier.volume10en_US
dc.identifier.wosWOS:000465188000014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofJournal Of Developmental Origins Of Health And Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdipokineen_US
dc.subjectBreast Milken_US
dc.subjectGrowthen_US
dc.subjectPreterm Infantsen_US
dc.subjectTerm Infantsen_US
dc.subjectWeight-Gainen_US
dc.subjectAssociationen_US
dc.subjectProteinsen_US
dc.subjectGlucoseen_US
dc.subjectGhrelinen_US
dc.subjectInsulinen_US
dc.subjectFetalen_US
dc.subjectSerumen_US
dc.titleDo the adiponectin and leptin levels in preterm and term breast milk samples relate to infants' short-term growth?en_US
dc.typeArticleen_US

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