Ceftriaxone induced acute generalized exanthematous pustulosis confirmed with patch test

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dc.authorscopusid59026366500
dc.authorscopusid57052759600
dc.authorscopusid58639863300
dc.authorscopusid36019067700
dc.authorscopusid55879012600
dc.contributor.authorUçar Ö.T.
dc.contributor.authorÖzdemir P.G.
dc.contributor.authorSarıkavak S.K.
dc.contributor.authorCan N.
dc.contributor.authorYazıcıoğlu M.
dc.date.accessioned2024-06-12T10:26:39Z
dc.date.available2024-06-12T10:26:39Z
dc.date.issued2023
dc.description.abstractBackground: Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous drug reaction presenting with rapid-onset sterile pustules on edematous erythema. Case: A 12-year-old female patient with acute gastroenteritis was consulted with complaints of pruritic erythema and high fever developing with small pustules on the 2nd day of ceftriaxone treatment. Lab tests showed an elevated absolute neutrophil count and lymphopenia. Ceftriaxone was discontinued immediately. The fever went away within 24 hours. According to EuroSCAR, the diagnosis of AGEP was confirmed. The skin biopsy was compatible with AGEP. After 6 weeks, a patch test with ceftriaxone was performed. A strong positive reaction to ceftriaxone was detected. Three months later, amoxicillin, amoxicillin-clavulanate, clarithromycin, and trimethoprim/sulfamethoxazole patch tests were performed, all were negative, and provocation tests were also planned. Conclusion: AGEP is a severe cutaneous drug reaction. We wanted to emphasize that patch tests help identify the responsible drug and find a safe alternative. © 2023 The authors. Published by Aydın Pediatric Society.en_US
dc.identifier.doi10.59213/TP.2023.27247
dc.identifier.endpage221en_US
dc.identifier.issn2792-0429
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85173777277en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage217en_US
dc.identifier.trdizinid1239044en_US
dc.identifier.urihttps://doi.org/10.59213/TP.2023.27247
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1239044
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16947
dc.identifier.volume4en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publishing Houseen_US
dc.relation.ispartofTrends in Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Generalized Exanthematous Pustulosis; Drug Eruption; Patch Test; Severe Drug Hypersensitivity Reactionsen_US
dc.titleCeftriaxone induced acute generalized exanthematous pustulosis confirmed with patch testen_US
dc.typeArticleen_US

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