Glu 298-Asp And T786-C Polymorphisms Of Endothelial Nitric Oxide Synthase Gene In Coronary Artery Disease Patients
Küçük Resim Yok
Tarih
2019
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Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: We aimed to investigate the association of eNOS gene with Glu298-Asp andT-786C polymorphisms with Coronary artery disease (CAD) and to contribute to theelucidation of the genetic factors involved in the development of CAD.Patients and Methods: A total of 200 patients were evaluated. Severe CAD was defined as ? 50% stenosis in at least one of major coronary arteries and these patientswere taken into the CAD group (n=144). Patients without stenosis were included inthe control group (n=66).Results: After the evaluation of T-786C polymorphism, there was no significant difference between TT (p=0,660), TC (p=0,73) and CC (p=0,634) genotypes betweenCAD and control groups. There was no significant difference between the groups inboth dominant (p=0,439) and recessive (p=0,622) model comparisons. When Glu298-Asp polymorphism was examined, there was no statistically significantdifference between GG (p=0,836), GT (p=0,581) and TT (p=0,767) genotypes whenthe groups were compared according to genotype distributions. The groups werestatistically similar according to both dominant (p=0,697) and recessive (p=0,485)model com-parisons.Conclusion: There was no statistical correlation between T-786 C and Glu 298-Asppolymorphisms and CAD. Similar studies with larger study populations should beconducted to clarify the role of T-786 C and Glu 298-Asp polymorphisms.
Açıklama
Anahtar Kelimeler
Kaynak
Acta Medica Alanya
WoS Q Değeri
Scopus Q Değeri
Cilt
3
Sayı
1
