Effects of Curcumin on Apoptosis and Oxidoinflammatory Regulation in a Rat Model of Acetic Acid-Induced Colitis: The Roles of c-Jun N-Terminal Kinase and p38 Mitogen-Activated Protein Kinase

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dc.authoridCerkezkayabekir, Aysegul/0000-0001-5537-1042
dc.authoridAkpolat Ferah, Meryem/0000-0002-3419-1728
dc.authoridUz, Yesim/0000-0002-0381-4590
dc.authorwosidCerkezkayabekir, Aysegul/Q-6629-2018
dc.authorwosidAkpolat Ferah, Meryem/ABD-3035-2020
dc.contributor.authorTopcu-Tarladacalisir, Yeter
dc.contributor.authorAkpolat, Meryem
dc.contributor.authorUz, Yesim Hulya
dc.contributor.authorKizilay, Gulnur
dc.contributor.authorSapmaz-Metin, Melike
dc.contributor.authorCerkezkayabekir, Aysegul
dc.contributor.authorOmurlu, Imran Kurt
dc.date.accessioned2024-06-12T10:52:22Z
dc.date.available2024-06-12T10:52:22Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe present study evaluated the effects of curcumin on epithelial cell apoptosis, the immunoreactivity of the phospho-c-Jun N-terminal kinase (JNK) and phospho-p38 mitogen-activated protein kinases (MAPKs) in inflamed colon mucosa, and oxidative stress in a rat model of ulcerative colitis induced by acetic acid. Rats were randomly divided into three groups: control, acetic acid, and acetic acid + curcumin. Curcumin (100 mg/kg per day, intragastrically) was administered 10 days before the induction of colitis and was continued for two additional days. Acetic acid-induced colitis caused a significant increase in the macroscopic and microscopic tissue ranking scores as well as an elevation in colonic myeloperoxidase (MPO) activity, malondialdehyde (MDA) levels, and the number of apoptotic epithelial cells in colon tissue compared to controls. In the rat colon, immunoreactivity of phospho-p38 MAPK was increased, whereas the phospho-JNK activity was decreased following the induction of colitis. Curcumin treatment was associated with amelioration of macroscopic and microscopic colitis sores, decreased MPO activity, and decreased MDA levels in acetic acid-induced colitis. Furthermore, oral curcumin supplementation clearly prevented programmed cell death and restored immunreactivity of MAPKs in the colons of colitic rats. The results of this study suggest that oral curcumin treatment decreases colon injury and is associated with decreased inflammatory reactions, lipid peroxidation, apoptotic cell death, and modulating p38- and JNK-MAPK pathways.en_US
dc.description.sponsorshipTrakya University Research Center [2009/154]en_US
dc.description.sponsorshipThe authors are grateful to the Trakya University Research Center for financial support of this study (Project no: 2009/154).en_US
dc.identifier.doi10.1089/jmf.2012.2550
dc.identifier.endpage305en_US
dc.identifier.issn1096-620X
dc.identifier.issn1557-7600
dc.identifier.issue4en_US
dc.identifier.pmid23566056en_US
dc.identifier.scopus2-s2.0-84876121485en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage296en_US
dc.identifier.urihttps://doi.org/10.1089/jmf.2012.2550
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18687
dc.identifier.volume16en_US
dc.identifier.wosWOS:000317352400005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal Of Medicinal Fooden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectColitisen_US
dc.subjectCurcuminen_US
dc.subjectMitogen-Activated Protein Kinaseen_US
dc.subjectOxidative Stressen_US
dc.subjectRaten_US
dc.subjectSignal-Transduction Pathwaysen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectOxidative Stressen_US
dc.subjectBarrier Functionen_US
dc.subjectPotential Roleen_US
dc.subjectExpressionen_US
dc.subjectInhibitionen_US
dc.subjectCellsen_US
dc.subjectMelatoninen_US
dc.subjectPreventsen_US
dc.titleEffects of Curcumin on Apoptosis and Oxidoinflammatory Regulation in a Rat Model of Acetic Acid-Induced Colitis: The Roles of c-Jun N-Terminal Kinase and p38 Mitogen-Activated Protein Kinaseen_US
dc.typeArticleen_US

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