Lithium promotes long-term neurological recovery after spinal cord injury in mice by enhancing neuronal survival, gray and white matter remodeling, and long-distance axonal regeneration

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dc.authoridDilsiz, Pelin/0000-0001-9192-5014
dc.authoridAYDIN, Mehmet Şerif/0000-0002-6393-1465
dc.authoridbalcikanli, zeynep/0000-0003-0039-3281
dc.authoridKOC, Halil Ibrahim/0000-0003-2562-1068
dc.authoridKilic, Ertugrul/0000-0001-6494-8923
dc.authorwosidDilsiz, Pelin/JAC-6423-2023
dc.authorwosidAYDIN, Mehmet Serif/B-4818-2015
dc.authorwosidBeker, Mustafa Caglar/ABH-2222-2020
dc.authorwosidAYDIN, Mehmet Şerif/JJF-6163-2023
dc.authorwosidHermann, Dirk M/AAP-5538-2020
dc.authorwosidbalcikanli, zeynep/JWQ-0860-2024
dc.authorwosidateş özsoy, nilay/JTS-5157-2023
dc.contributor.authorBalcikanli, Zeynep
dc.contributor.authorCulha, Irem
dc.contributor.authorDilsiz, Pelin
dc.contributor.authorAydin, Mehmet Serif
dc.contributor.authorAtes, Nilay
dc.contributor.authorBeker, Mustafa Caglar
dc.contributor.authorBaltaci, Saltuk Bugra
dc.date.accessioned2024-06-12T10:54:07Z
dc.date.available2024-06-12T10:54:07Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSpinal cord injury (SCI) induces neurological deficits associated with long-term functional impairments. Since the current treatments remain ineffective, novel therapeutic options are needed. Besides its effect on bipolar mood disorder, lithium was reported to have neuroprotective activity in different neurodegenerative conditions, including SCI. In SCI, the effects of lithium on long-term neurological recovery and neuroplasticity have not been assessed. We herein investigated the effects of intraperitoneally administered lithium chloride (LiCl) on motor coordination recovery, electromyography (EMG) responses, histopathological injury and remodeling, and axonal plasticity in mice exposed to spinal cord transection. At a dose of 0.2, but not 2.0 mmol/kg, LiCl enhanced motor coordination and locomotor activity starting at 28 days post-injury (dpi), as assessed by a set of behavioral tests. Following electrical stimulation proximal to the hemitransection, LiCl at 0.2 mmol/kg decreased the latency and increased the amplitude of EMG responses in the denervated hindlimb at 56 dpi. Functional recovery was associated with reduced gray and white matter atrophy rostral and caudal to the hemitransection, increased neuronal survival and reduced astrogliosis in the dorsal and ventral horns caudal to the hemitransection, and increased regeneration of long-distance axons proximal and distal to the lesion site in mice receiving 0.2 mmol/kg, but not 2 mmol/kg LiCl, as assessed by histochemical and immunohistochemical studies combined with anterograde tract tracing. Our results indicate that LiCl induces long-term neurological recovery and neuroplasticity following SCI.en_US
dc.description.sponsorshipTurkish Academy of Sciences (TUBA); Istanbul Medipol Universityen_US
dc.description.sponsorshipEK was supported by the Turkish Academy of Sciences (TUBA) and this study was by Istanbul Medipol University.en_US
dc.identifier.doi10.3389/fncel.2022.1012523
dc.identifier.issn1662-5102
dc.identifier.pmid36439202en_US
dc.identifier.scopus2-s2.0-85142652745en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3389/fncel.2022.1012523
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18929
dc.identifier.volume16en_US
dc.identifier.wosWOS:000890502600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers In Cellular Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAxonal Plasticityen_US
dc.subjectAxonal Regenerationen_US
dc.subjectMotor Coordinationen_US
dc.subjectNeurological Recoveryen_US
dc.subjectSpinal Cord Hemitransectionen_US
dc.subjectSpinal Cord Traumaen_US
dc.subjectFocal Cerebral-Ischemiaen_US
dc.subjectTraumatic Brain-Injuryen_US
dc.subjectMotor Recoveryen_US
dc.subjectPlasticityen_US
dc.subjectApoptosisen_US
dc.subjectMelatoninen_US
dc.subjectAntibodyen_US
dc.subjectDeficitsen_US
dc.subjectTherapyen_US
dc.subjectScaleen_US
dc.titleLithium promotes long-term neurological recovery after spinal cord injury in mice by enhancing neuronal survival, gray and white matter remodeling, and long-distance axonal regenerationen_US
dc.typeArticleen_US

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