An experimental study: the effect of S. boulardii on abemaciclib-induced diarrhea

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dc.contributor.authorCakcak, Ibrahim Ethem
dc.contributor.authorAytin, Yusuf Emre
dc.contributor.authorSayin, Sezin
dc.contributor.authorKucukarda, Ahmet
dc.contributor.authorGokyer, Ali
dc.contributor.authorGokmen, Ivo
dc.contributor.authorOzcan, Erkan
dc.date.accessioned2024-06-12T10:55:10Z
dc.date.available2024-06-12T10:55:10Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/aim: In our study, we aimed to investigate the protective effects of Saccharomyces boulardii on abemaciclib-induced diarrhea model, which is a commonly used drug in breast cancer. Materials and methods: Thirty rats were divided into 3 groups as control (Group 1), abemaciclib (Group 2), and abemaciclib + Saccharomyces boulardii (Group 3) groups. The clinical status, body weight, and defecation status were monitored daily. At the end of the 15-day experiment period, the rats were killed with high-dose anesthesia and the resected small intestine segments were evaluated histopathologically. Lesions were classified according to thickening of the villus, inflammation and edema of mucosa and intraepithelial leukocyte accumulation. Then, mean values of both crypt depths and villi thicknesses were calculated for each rat. Normal distribution assumption was controlled with the Shapiro-Wilk test. One-way analysis of variance for normally distributed variables in the comparisons of more than two independent groups and Kruskal-Wallis test for nonnormally distributed variables were used. The significance value was accepted as 0.05. Results: There was one death in Group 3, but none in the others. There were no findings of mucositis in Group I. There was mild diarrhea and weight loss in only one rat in Group 1. For the comparison of the severity of diarrhea (72.5%/39%) and weight loss (72.5%/45%), a decrease was found in Group 3 according to Group 2 (p < 0.01). Histopathological findings such as edema, inflammation, and intraepithelial leukocyte accumulation also showed a decrease in Group 3 compared to Group 2 (p < 0.01). Conclusion: Saccharomyces boulardii should be considered as a treatment option in abaemaciclib (chemotherapy)-induced diarrhea. Further comparative studies and in vivo human randomized controlled studies can be conducted in the future.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Unit [2022/16]en_US
dc.description.sponsorshipAcknowledgment/disclaimers/conflict of interest This present work was supported by the Trakya University Scientific Research Projects Unit (project number: 2022/16) . The authors declare no conflicts of interest.en_US
dc.identifier.doi10.55730/1300-0144.5557
dc.identifier.endpage57en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.pmid36945921en_US
dc.identifier.scopus2-s2.0-85149224480en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage51en_US
dc.identifier.trdizinid1159850en_US
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5557
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1159850
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19318
dc.identifier.volume53en_US
dc.identifier.wosWOS:000941667500008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast Canceren_US
dc.subjectAbemacicliben_US
dc.subjectSaccharomyces Boulardiien_US
dc.subjectDiarrheaen_US
dc.subjectAntibiotic-Associated Diarrheaen_US
dc.subjectChemotherapy-Induced Diarrheaen_US
dc.subjectBreast-Canceren_US
dc.subjectSaccharomyces-Boulardiien_US
dc.subjectDouble-Blinden_US
dc.subjectProbioticsen_US
dc.subjectPreventionen_US
dc.subjectIrinotecanen_US
dc.subjectTherapyen_US
dc.subjectFulvestranten_US
dc.titleAn experimental study: the effect of S. boulardii on abemaciclib-induced diarrheaen_US
dc.typeArticleen_US

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