The effects of citric acid (antioxidant) and benzoic acid (antimicrobial agent) on the mouse liver: biochemical and histopathological study

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dc.authoridCerkezkayabekir, Aysegul/0000-0001-5537-1042
dc.authoridErtan, Figen/0000-0002-7882-3993
dc.authorwosidCerkezkayabekir, Aysegul/Q-6629-2018
dc.contributor.authorAktac, T
dc.contributor.authorKaboglu, A
dc.contributor.authorErtan, F
dc.contributor.authorEkinci, F
dc.contributor.authorHuseyinova, G
dc.date.accessioned2024-06-12T10:56:35Z
dc.date.available2024-06-12T10:56:35Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe damaging effects of citric acid and benzoic acid on mouse liver were reported. Aqueous solutions of citric acid and benzoic acid (concentrations 0.01% and 0.02%) were administered to male mice as drinking water. After 10 days, it was observed that the necrotic changes (vacuolated and glassy cytoplasm in hepatocytes, chromatin decrease, and increase of collagen fibers amongst hepatocytes) occurred in livers of all experimental groups. Uricase activity significantly increased in all treated groups (p < 0.01, p < 0.001, p < 0.002) compared to the controls. However, there was no statistically significant increase in catalase activity (p < 0.1).en_US
dc.identifier.endpage347en_US
dc.identifier.issn0006-3088
dc.identifier.issn1336-9563
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-0346958336en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage343en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19847
dc.identifier.volume58en_US
dc.identifier.wosWOS:000184337600008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofBiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCitric Aciden_US
dc.subjectBenzoic Aciden_US
dc.subjectUricaseen_US
dc.subjectCatalaseen_US
dc.subjectMouseen_US
dc.subjectLiveren_US
dc.subjectFood Preservativesen_US
dc.subjectRatsen_US
dc.subjectGlutathioneen_US
dc.titleThe effects of citric acid (antioxidant) and benzoic acid (antimicrobial agent) on the mouse liver: biochemical and histopathological studyen_US
dc.typeArticleen_US

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