Acute Lymphoblastic Leukemia; Prognostic Factors' Perspective

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dc.authoridAKPINAR, SEVAL/0000-0002-6961-8971
dc.authorwosidAKPINAR, SEVAL/HKD-9650-2023
dc.contributor.authorTekgunduz, Emre
dc.contributor.authorDemir, Muzaffer
dc.contributor.authorAkpinar, Seval
dc.date.accessioned2024-06-12T10:50:34Z
dc.date.available2024-06-12T10:50:34Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAcute lymphoblastic leukemia represents a biologically and clinically heterogeneous group of diseases with different outcomes among patients subgroups. Identification of prognostic factors is critical in selecting therapy for subgroups of patients to achieve a high cure rate with minimal toxicity. Another important goal of risk stratification is to define patients with a very high risk of relaps, who may benefit from up-front allogeneic hematopoietic stem cell transplantation following first complete remission. Clinical parameters, immunophenotype, cytogenetics, treatment response, minimal residual disease are among currently used factors in risk stratification of acute lymphoblastic leukemia patients. But there are emerging new parameters like global gene expression profiling, host pharmacodynamics-pharmacogenetics and treatment protocols which may have an impact on risk-adapted treatment in the near future. In the present review we will discuss a variety of prognostic factors and their impact on clinical outcome of children and adults with acute lymphoblastic leukemia.en_US
dc.identifier.endpage66en_US
dc.identifier.issn1306-133X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-77950408372en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18053
dc.identifier.volume20en_US
dc.identifier.wosWOS:000275961900011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherAkad Doktorlar Yayinevien_US
dc.relation.ispartofUhod-Uluslararasi Hematoloji-Onkoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Lymphoblastic Leukemiaen_US
dc.subjectPrognosisen_US
dc.subjectRisk Factorsen_US
dc.subjectMinimal Residual Diseaseen_US
dc.subjectGene-Expression Patternsen_US
dc.subjectClinical Characteristicsen_US
dc.subjectDrug-Therapyen_US
dc.subjectGroup-Ben_US
dc.subjectChildrenen_US
dc.subjectClassificationen_US
dc.subjectChemotherapyen_US
dc.subjectAdolescentsen_US
dc.subjectPredictsen_US
dc.titleAcute Lymphoblastic Leukemia; Prognostic Factors' Perspectiveen_US
dc.typeReview Articleen_US

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