The Role of Hydrogen Sulfide in the Development of Tolerance and Dependence to Morphine in Mice

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dc.authoridGunduz, Ozgur/0000-0002-2470-3021;
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.authorwosidçetin, zeynep/HHD-1705-2022
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.contributor.authorCetin, Zeynep
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorTopuz, Ruhan D.
dc.contributor.authorDokmeci, Dikmen
dc.contributor.authorKaradag, Hakan C.
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T11:08:43Z
dc.date.available2024-06-12T11:08:43Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Hydrogen sulfide is an endogenous gaseous mediator that has been indicated to have a role in pain mechanisms. In this study, we aimed to detect brain and spinal cord hydrogen sulfide levels during different phases of tolerance and dependence to morphine and to determine the effects of inhibition of endogenous hydrogen sulfide production on the development of tolerance and dependence. Methods: Morphine tolerance and dependence was developed by subcutaneous injection of morphine (10 mg/kg) twice daily for 12 days. Physical dependence was determined by counting the jumps for 20 min, which is a withdrawal symptom occurring after a single dose of naloxone (5 mg/kg) administered intraperitoneally (i.p.). Propargylglycine (30 mg/kg, i.p.), a cystathionine-gamma-lyase inhibitor, and hydroxylamine (12.5 mg/kg, i.p.), a cystathionine-beta-synthase inhibitor, were used as hydrogen sulfide synthase inhibitors. The tail-flick and hot-plate tests were used to determine the loss of antinociceptive effects of morphine and development of tolerance. Results: It was found that chronic and acute uses of both propargylglycine and hydroxylamine prevented the development of tolerance to morphine, whereas they had no effect on morphine dependence. Chronic and acute administrations of hydrogen sulfide synthase inhibitors did not exert any difference in hydrogen sulfide levels in brain and spinal cords of both morphine-tolerant and -dependent animals. Conclusion: It has been concluded that hydrogen sulfide synthase inhibitors may have utility in preventing morphine tolerance.en_US
dc.description.sponsorshipResearch Fund of Trakya University [TUBAP-2016/209]en_US
dc.description.sponsorshipThis work was supported by Research Fund of Trakya University (TUBAP-2016/209).en_US
dc.identifier.doi10.1159/000511541
dc.identifier.endpage270en_US
dc.identifier.issn0302-282X
dc.identifier.issn1423-0224
dc.identifier.issue3en_US
dc.identifier.pmid33207349en_US
dc.identifier.scopus2-s2.0-85096652195en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage264en_US
dc.identifier.urihttps://doi.org/10.1159/000511541
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22543
dc.identifier.volume80en_US
dc.identifier.wosWOS:000590578000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofNeuropsychobiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMorphineen_US
dc.subjectToleranceen_US
dc.subjectDependenceen_US
dc.subjectHydrogen Sulfideen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectPhysical-Dependenceen_US
dc.subjectNeuropathic Painen_US
dc.subjectMechanismsen_US
dc.titleThe Role of Hydrogen Sulfide in the Development of Tolerance and Dependence to Morphine in Miceen_US
dc.typeArticleen_US

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