Role of caffeic acid phenethyl ester, an active component of propolis, against NAOH-induced esophageal burns in rats

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dc.contributor.authorOcakci, Ayse
dc.contributor.authorKanter, Mehmet
dc.contributor.authorCabuk, Mehmet
dc.contributor.authorBuyukbas, Sadik
dc.date.accessioned2024-06-12T10:55:28Z
dc.date.available2024-06-12T10:55:28Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: This study was evaluated to investigate the efficacy of caffeic acid phenethyl ester (CAPE), which is a natural honeybee product exhibits a spectrum of biological activities including anti-microbial, anti-inflammatory, antioxidant and anti-tumoral actions, on the prevention of stricture development after esophageal caustic injuries in the rat. Methods: Thirty healthy mate Wistar albino rats were utilized in this study. The rats were randomly allotted into one of three experimental groups: group A (sham) animals were uninjured. Caustic esophageal burn was created by applying 1 ml 37.5% NaOH to the distal esophagus. Group B rats were injured but untreated. Group C rats were injured and received CAPE (10 mu mol/kg/day i.p. for 28 days). Efficacy of the treatment was assessed by measuring the esophageal transit time, stenosis index, histopathologic damage score and biochemically by determining tissue hydroxyproline content, lipid peroxidation and antioxidant enzyme activities. Results: The esophageal. transit time, the stenosis index, histopathologic damage score and the hydroxyproline level were significantly increased in the untreated group compared with the sham and CAPE-treated groups. Treatment with CAPE decreased tissue hydroxyproline Levels, histological damage, and the stenosis index, but except the esophageal transit time. Caustic esophageal burn also increased the lipid peroxidation and decreased the antioxidant enzyme activities in the untreated group. CAPE treatments decreased the elevated lipid peroxidation and also increased the reduced antioxidant enzyme activities. In corrosive esophageal burn group with no treatment, the most consistent findings were degenerative changes and increased in submucosal collagen content, and the luminal narrowing. CAPE treatment protected esophagus. Nevertheless, there was the slight increase in submucosal collagen. Conclusions: It is concluded that CAPE has a preventive effect on the stricture development after esophageal caustic injuries in the rat. (C) 2006 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijporl.2006.05.018
dc.identifier.endpage1739en_US
dc.identifier.issn0165-5876
dc.identifier.issue10en_US
dc.identifier.pmid16828884en_US
dc.identifier.scopus2-s2.0-33747893741en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1731en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2006.05.018
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19438
dc.identifier.volume70en_US
dc.identifier.wosWOS:000240782400008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Pediatric Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectCaustic Burnen_US
dc.subjectStrictureen_US
dc.subjectFibrosisen_US
dc.subjectLipid Peroxidationen_US
dc.subjectAntioxidant Enzyme Activitiesen_US
dc.subjectEpidermal Growth-Factoren_US
dc.subjectReperfusion Injuryen_US
dc.subjectCorrosive Burnsen_US
dc.subjectCaustic Ingestionen_US
dc.subjectAlpha-Tocopherolen_US
dc.subjectAlkali Burnsen_US
dc.subjectAntioxidanten_US
dc.subjectChildrenen_US
dc.subjectStrictureen_US
dc.subjectCollagenen_US
dc.titleRole of caffeic acid phenethyl ester, an active component of propolis, against NAOH-induced esophageal burns in ratsen_US
dc.typeArticleen_US

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