The relationship between leukemoid reaction and perinatal morbidity, mortality, and chorioamnionitis in low birth weight infants

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dc.authoridOzbek, Ugur/0000-0001-5319-0547;
dc.authorwosidOzbek, Ugur/C-9513-2017
dc.authorwosidDuran, Rıdvan/C-1065-2015
dc.contributor.authorDuran, Ridvan
dc.contributor.authorOzbek, Ulfet Vatansever
dc.contributor.authorCiftdemir, Nukhet Aladag
dc.contributor.authorAcunas, Betul
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:09:03Z
dc.date.available2024-06-12T11:09:03Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description17th National Congress of Neonatology -- APR 27-30, 2009 -- Cesme, TURKEYen_US
dc.description.abstractObjectives: Neonatal leukemoid reaction (NLR) is relatively rare and considered as a white blood cell (WBC) count >= 50 x 10(9)/l. The aim of this study was to investigate the association of NLR with neonatal morbidity and mortality and maternal chorioamnionitis in low birth weight infants. Methods: In this case-controlled retrospective study, the medical records of 1200 newborn infants with a birth weight <2500 g admitted to the neonatal unit over a period of 5 years were reviewed. The infants who developed features of NLR (n = 17, 1.4%) formed the study group, while the remainder without NLR, matched for gestational age and birth weight (n = 123), formed the control group. A chart review was performed and salient demographic, clinical, and laboratory data abstracted. A statistical analysis was subsequently performed on this data. Results: The mean WBC and absolute neutrophil counts of infants with NLR were significantly higher than those in the control group. The peak time of NLR was at 7.9 +/- 3.6 (interquartile range (IQR) 1-30) days and on average it improved within 4.1 +/- 1.95 (IQR 2-9) days. It was noted that those infants with NLR were mostly born by vaginal delivery and their mothers had a higher rate of early rupture of the membranes and chorioamnionitis. NLR was associated with a 4-fold increase in sepsis, 20-fold increase in intraventricular hemorrhage, 54-fold increase in bronchopulmonary dysplasia, and 6-fold increase in mortality. In the study group, those infants whose mothers had chorioamnionitis had a higher rate of early rupture of the membranes and they developed sepsis and intraventricular hemorrhage more often than those whose mothers did not have clinical chorioamnionitis. Conclusions: In low birth weight newborn infants, NLR is significantly associated with sepsis, intraventricular hemorrhage, bronchopulmonary dysplasia, and a high mortality rate. Also, those infants with NLR are more likely to be born to mothers with chorioamnionitis and they face sepsis and intraventricular hemorrhage more often. (C) 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijid.2010.06.012
dc.identifier.endpageE1001en_US
dc.identifier.issn1201-9712
dc.identifier.issn1878-3511
dc.identifier.issue11en_US
dc.identifier.pmid20851018en_US
dc.identifier.scopus2-s2.0-78149467465en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE998en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijid.2010.06.012
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22673
dc.identifier.volume14en_US
dc.identifier.wosWOS:000284059300010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofInternational Journal Of Infectious Diseasesen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeonatal Leukemoid Reactionen_US
dc.subjectChorioamnionitisen_US
dc.subjectMorbidityen_US
dc.subjectMortalityen_US
dc.subjectBronchopulmonary Dysplasiaen_US
dc.subjectOutcomesen_US
dc.titleThe relationship between leukemoid reaction and perinatal morbidity, mortality, and chorioamnionitis in low birth weight infantsen_US
dc.typeConference Objecten_US

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