Factors affecting local control, distant recurrence and survival in patients with locally advanced bladder cancer treated by definitive radiotherapy or chemoradiotherapy

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dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authorwosidCosar, Rusen/GQP-7875-2022
dc.authorwosidIbis, Kamuran/AAD-1939-2019
dc.authorwosidKaplan, Mustafa/D-4977-2014
dc.authorwosidCosar, Rusen/AAC-4045-2020
dc.contributor.authorCaloglu, Murat
dc.contributor.authorYurut-Caloglu, Vuslat
dc.contributor.authorSaynak, Mert
dc.contributor.authorCosar-Alas, Rusen
dc.contributor.authorKaragol, Hakan
dc.contributor.authorKaplan, Mustafa
dc.contributor.authorIbis, Kamuran
dc.date.accessioned2024-06-12T10:54:48Z
dc.date.available2024-06-12T10:54:48Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVES Treatment results of 34 patients with bladder cancer admitted to Department of Radiation Oncology, Medicine Faculty of Trakya University between October 1997 and June 2005 were retrospectively analyzed. Prognostic factors associated with survival were determined. METHODS Their median age was 69 years (range 44-93). Thirty patients (88%) were male and 4 patients (12%) were female. Histopathological diagnosis was transitional cell carcinoma in 20 (59%) patients. Chemotherapy was administered concomitantly with radiotherapy to the 11 (32.35%) of the patients. The median radiotherapy dose was 62.5 (35-68) Gy. The median follow-up was 22 months (5-76 months). Median survival and median disease-free survival were 14.2 months (3.8-57.5) and 10 months (0-55), respectively. RESULTS Three years loco-regional control, metastasis free survival, disease free survival and overall survival rates were 76.59 , 72.2%, 55% and 41.1%, respectively. Epidermoid carcinoma histopathology (p=0.002), not performing concomitant chemotherapy (p=0.003), applying carboplatin instead of cisplatin with radiotherapy (p=0.004) and not conducting complete TURB (p=0.008) were significant poor prognostic factors on loco-regional control. Undifferentiated cell type (p=0.012) and not performing concomitant chemotherapy (p=0.046) were significant adverse factors on distant metastases. Factors that affect overall survival were tumor in stage T-4 (p=0.05), hemoglobin value below 10 g/dl (p=0.032) and not performing concomitant chemo-radiotherapy (p=0.017) and complete TURB (p=0.049). CONCLUSION Complications of radiotherapy were acceptable. For the treatment of muscle invasive locally advanced bladder cancer, RT combined with cisplatin is an acceptable treatment option. Moreover, complete TURB before RT is important both for local control and for survival.en_US
dc.identifier.endpage167en_US
dc.identifier.issn1300-7467
dc.identifier.issue4en_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19185
dc.identifier.volume21en_US
dc.identifier.wosWOS:000439249500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherKare Publen_US
dc.relation.ispartofTurk Onkoloji Dergisi-Turkish Journal Of Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBladder Neoplasms/Mortality/Radiotherapy/Therapyen_US
dc.subjectCisplatin/Dosageen_US
dc.subjectRadiotherapy Dosageen_US
dc.subjectSurvival Rateen_US
dc.subjectTransitional-Cell-Carcinomaen_US
dc.subjectCombined-Modality Treatmenten_US
dc.subjectExternal-Beam Radiotherapyen_US
dc.subjectBacillus-Calmette-Guerinen_US
dc.subjectRadical Radiotherapyen_US
dc.subjectRadiation-Therapyen_US
dc.subjectRetrospective Analysisen_US
dc.subjectPrognostic Variablesen_US
dc.subjectOrgan Preservationen_US
dc.subjectCystectomyen_US
dc.titleFactors affecting local control, distant recurrence and survival in patients with locally advanced bladder cancer treated by definitive radiotherapy or chemoradiotherapyen_US
dc.typeArticleen_US

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