Headache in idiopathic/genetic epilepsy: Cluster analysis in a large cohort

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dc.authoridÖzge, Aynur Avcı/0000-0003-2797-2398
dc.authoridüstün özek, sibel/0000-0003-1165-2648
dc.authoridDuzgun, Ulkuhan/0000-0001-9759-6960
dc.authoridTurk, Bengi Gul/0000-0003-1839-5971
dc.authoridGENC, BULENT OGUZ/0000-0002-5652-1337
dc.authoridKoc, Guray/0000-0002-2477-5244
dc.authoridVelioglu, Sibel K/0000-0003-0352-702X
dc.authorwosidErdal, Yüksel/ABF-1818-2021
dc.authorwosidÖzge, Aynur Avcı/AFB-2183-2022
dc.authorwosidbebek, nerses/W-7266-2019
dc.authorwosidüstün özek, sibel/GVS-4240-2022
dc.authorwosidDuzgun, Ulkuhan/GYQ-6191-2022
dc.authorwosidTurk, Bengi Gul/AAZ-8014-2020
dc.authorwosidGENC, BULENT OGUZ/KLZ-4232-2024
dc.contributor.authorAtalar, Arife Cimen
dc.contributor.authorTurk, Bengi Gul
dc.contributor.authorEkizoglu, Esme
dc.contributor.authorGok, Duygu Kurt
dc.contributor.authorBaykan, Betul
dc.contributor.authorOzge, Aynur
dc.contributor.authorAyta, Semih
dc.date.accessioned2024-06-12T10:56:42Z
dc.date.available2024-06-12T10:56:42Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective The link between headache and epilepsy is more prominent in patients with idiopathic/genetic epilepsy (I/GE). We aimed to investigate the prevalence of headache and to cluster patients with regard to their headache and epilepsy features. Methods Patients aged 6-40 years, with a definite diagnosis of I/GE, were consecutively enrolled. The patients were interviewed using standardized epilepsy and headache questionnaires, and their headache characteristics were investigated by experts in headache. Demographic and clinical variables were analyzed, and patients were clustered according to their epilepsy and headache characteristics using an unsupervised K-means algorithm. Results Among 809 patients, 508 (62.8%) reported having any type of headache; 87.4% had interictal headache, and 41.2% had migraine. Cluster analysis revealed two distinct groups for both adults and children/adolescents. In adults, subjects having a family history of headache, >= 5 headache attacks, duration of headache >= 24 months, headaches lasting >= 1 h, and visual analog scale scores > 5 were grouped in one cluster, and subjects with juvenile myoclonic epilepsy (JME), myoclonic seizures, and generalized tonic-clonic seizures (GTCS) were clustered in this group (Cluster 1). Self-limited epilepsy with centrotemporal spikes and epilepsy with GTCS alone were clustered in Cluster 2 with the opposite characteristics. For children/adolescents, the same features as in adult Cluster 1 were clustered in a separate group, except for the presence of JME syndrome and GTCS alone as a seizure type. Focal seizures were clustered in another group with the opposite characteristics. In the entire group, the model revealed an additional cluster, including patients with the syndrome of GTCS alone (50.51%), with >= 5 attacks, headache lasting >4 h, and throbbing headache; 65.66% of patients had a family history of headache in this third cluster (n = 99). Significance Patients with I/GE can be clustered into distinct groups according to headache features along with seizures. Our findings may help in management and planning for future studies.en_US
dc.description.sponsorshipGlobal Migraine and Pain Societyen_US
dc.description.sponsorshipWe especially want to thank the Turkish Epilepsy Society (Turkish chapter of ILAE) for their unconditional support at every step of this multicenter study, including the design and conduct of the study, as well as allowing us to use their official website to introduce the design of the study and reach the related forms and materials. The authors also want to thank the Global Migraine and Pain Society for its unconditional support and Dr Betul Tekin for her contributions to the study.en_US
dc.identifier.doi10.1111/epi.17205
dc.identifier.endpage1529en_US
dc.identifier.issn0013-9580
dc.identifier.issn1528-1167
dc.identifier.issue6en_US
dc.identifier.pmid35188224en_US
dc.identifier.scopus2-s2.0-85127593682en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1516en_US
dc.identifier.urihttps://doi.org/10.1111/epi.17205
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19888
dc.identifier.volume63en_US
dc.identifier.wosWOS:000778606700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEpilepsiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCluster Analysisen_US
dc.subjectGenetic Epilepsyen_US
dc.subjectHeadacheen_US
dc.subjectHeadache Phenotypesen_US
dc.subjectIdiopathic Epilepsyen_US
dc.subjectMyoclonic Seizuresen_US
dc.subjectJuvenile Myoclonic Epilepsyen_US
dc.subjectUnited-Statesen_US
dc.subjectMigraineen_US
dc.subjectChildhooden_US
dc.subjectChildrenen_US
dc.subjectBurdenen_US
dc.subjectClassificationen_US
dc.subjectPrevalenceen_US
dc.subjectMigralepsyen_US
dc.subjectMechanismsen_US
dc.titleHeadache in idiopathic/genetic epilepsy: Cluster analysis in a large cohorten_US
dc.typeArticleen_US

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