The protective effect of oral magnesium supplement on noise-induced hearing loss

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dc.authorscopusid57198272452
dc.authorscopusid6602357375
dc.authorscopusid55962507400
dc.authorscopusid7005413886
dc.authorscopusid15021910100
dc.authorscopusid6602899799
dc.contributor.authorYildirim C.
dc.contributor.authorYagiz R.
dc.contributor.authorUzun C.
dc.contributor.authorTaş A.
dc.contributor.authorBulut E.
dc.contributor.authorKarasalihoglu A.
dc.date.accessioned2024-06-12T10:28:45Z
dc.date.available2024-06-12T10:28:45Z
dc.date.issued2006
dc.description.abstractOBJECTIVES: We investigated the beneficial effect of magnesium in the prevention of noise-induced cochlear damage in guinea pigs by transient evoked otoacoustic emissions (TEOAE). STUDY DESIGN: Thirty-nine guinea pigs with normal auropalpebral reflex were randomly divided into control (n=20) and study (n=19) groups. All the animals were subjected to wide-band noise standardized at a mean of 98+/-2 dB for 16 hours a day for 10 days in a sound isolated cabin. The study animals received 39 mmol/l MgCl2 throughout the study period starting from 15 days before noise exposure. Otomicroscopic examination, auditory brain stem response (ABR) and TEOAE measurements were performed before and after noise exposure. Tympanometric measurements were performed to eliminate possible middle ear pathologies. RESULTS: Although the mean TEOAE response and reproducibility values showed significant decreases after noise application in the control group (p<0.001), they were not affected significantly in magnesium-treated animals. Post-exposure mean TEOAE response and reproducibility values significantly differed between the two groups (p<0.001). Noise-induced elevations in ABR thresholds were significant in both groups (p<0.001); however, it was noted that hearing levels were better preserved in the study group. CONCLUSION: Our data suggest that oral magnesium intake may be beneficial in the prevention of cochlear damage in noise-induced hearing loss.en_US
dc.identifier.endpage36en_US
dc.identifier.issn1300-7475
dc.identifier.issue1en_US
dc.identifier.pmid16763412en_US
dc.identifier.scopus2-s2.0-33750111762en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17403
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.relation.ispartofKulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throaten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMagnesium Chloride; Animal; Article; Diet Supplementation; Disease Model; Guinea Pig; Noise Injury; Oral Drug Administration; Spontaneous Otoacoustic Emission; Administration, Oral; Animals; Dietary Supplements; Disease Models, Animal; Guinea Pigs; Hearing Loss, Noise-Induced; Magnesium Chloride; Otoacoustic Emissions, Spontaneousen_US
dc.titleThe protective effect of oral magnesium supplement on noise-induced hearing lossen_US
dc.title.alternativeGürültüye bagli işitme kaybinda magnezyumun koruyucu etkisi.en_US
dc.typeArticleen_US

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