The roles of MTHFR (C677T, A1298C) and MGP (G-7A, T-138C) gene variations in development of diabetic nephropathy in patients with type 2 diabetes mellitus

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dc.authoridKurt, Idris/0000-0001-5966-1055
dc.authoridUstundag, Sedat/0000-0002-8502-9181
dc.authoridAlkanli, Nevra/0000-0002-3745-8838
dc.authorwosidKurt, Idris/AEX-6625-2022
dc.authorwosidAlkanli, Nevra/D-4400-2019
dc.contributor.authorAy, Arzu
dc.contributor.authorAlkanli, Nevra
dc.contributor.authorKurt, Idris
dc.contributor.authorUstundag, Sedat
dc.contributor.authorSipahi, Tammam
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T10:59:28Z
dc.date.available2024-06-12T10:59:28Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground The goal of this study is to determine the role of MTHFR (C677T, A1298C) and MGP (G-7A, T-138C) gene variations in DN development. Methods There were 61 DN patients and 55 healthy controls in this study. The genotype distributions of these gene variations were determined using PCR and RFLP methods. Results According to our study, there was no significant relationship between these gene variations and DN (p > 0.05). The allele frequencies of the MTHFR C677T gene variation in the control group were found significantly different from the Hardy-Weinberg distribution (p < 0.05). According to combined genotype analysis, GA-TT combined genotype of MGP (G-7A/T-138C) gene variations was observed significantly more in the patient group with DN. The GA-TT combined genotype of MGP (G-7A/T-138C) gene variations was differ significantly between these groups (OR: 2.359, %95 CI: 1.094-5.087, p = 0.028). Conclusion In our study, although MTHFR and MGP gene variations were not risk factors, the GA-TT combined genotype of the MGP (G-7A/T-138C) gene variation was detected as an important risk factor for DN.en_US
dc.identifier.doi10.1007/s40200-022-01061-9
dc.identifier.endpage1326en_US
dc.identifier.issn2251-6581
dc.identifier.issue2en_US
dc.identifier.pmid36404848en_US
dc.identifier.scopus2-s2.0-85131581216en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1317en_US
dc.identifier.urihttps://doi.org/10.1007/s40200-022-01061-9
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20459
dc.identifier.volume21en_US
dc.identifier.wosWOS:000807298100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Int Publ Agen_US
dc.relation.ispartofJournal Of Diabetes And Metabolic Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetic Nephropathyen_US
dc.subjectMTHFR (C677Ten_US
dc.subjectA1298C) Gene Variationsen_US
dc.subjectMGP (G-7Aen_US
dc.subjectT-138C) Gene Variationsen_US
dc.subjectPCRen_US
dc.subjectRFLPen_US
dc.subjectMatrix Gla Proteinen_US
dc.subjectMethylenetetrahydrofolate Reductaseen_US
dc.subjectVascular Calcificationen_US
dc.subjectPolymorphismsen_US
dc.subjectRisken_US
dc.titleThe roles of MTHFR (C677T, A1298C) and MGP (G-7A, T-138C) gene variations in development of diabetic nephropathy in patients with type 2 diabetes mellitusen_US
dc.typeArticleen_US

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