Synthesis of new bio-based hydrogels derived from bile acids by free-radical photo-polymerization

Basit Öğe Kaydı
dc.authoridKARABULUT, H R Ferhat/0000-0002-9501-6296
dc.authoridKARATAVUK, Ali Osman/0000-0001-6616-4065
dc.authoridAcik, Gokhan/0000-0002-9427-0508
dc.authoridAltinkok, Cagatay/0000-0002-0262-4154
dc.authorwosidKARABULUT, H R Ferhat/AAA-1402-2021
dc.authorwosidKARATAVUK, Ali Osman/AAE-8175-2019
dc.authorwosidAcik, Gokhan/M-5880-2019
dc.authorwosidAltinkok, Cagatay/ABA-9208-2020
dc.contributor.authorKarabulut, Huseyin Riza Ferhat
dc.contributor.authorMert, Berk
dc.contributor.authorAltinkok, Cagatay
dc.contributor.authorKaratavuk, Ali Osman
dc.contributor.authorAcik, Gokhan
dc.contributor.authorTurkyilmaz, Murat
dc.date.accessioned2024-06-12T10:54:29Z
dc.date.available2024-06-12T10:54:29Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn this article, the study on the swelling and thermal behaviors of a new series of bile acid-based polymeric hydrogels is reported. For this purpose, in the first step, the reduction of carboxyl acid groups of some common bile acids including cholic acid (CA), chenodeoxy cholic acid (CDCA), and lithocholic acid (LCA) to the corresponding alcohols by lithium aluminum hydride (LiAlH4) in THF solution is performed. Then, hydroxyl functionalities of the obtained products are reacted with the acryloyl chloride in the presence of triethylamine (TEA). Finally, the cross-linking reactions between acryloyl functionalized bile acids and methoxy poly(ethylene glycol) monomethacrylate (MPEGMA) are conducted by free-radical photo-polymerization technique at lambda = 350 nm in the presence of 2,2-Dimethoxy-2-phenylacetophenone (DMPA) as an initiator to achieve the desired bile acid-based polymeric hydrogels. The resulting hydrogels and their intermediates are characterized by Fourier transform infrared (FT-IR) and Proton nuclear magnetic resonance (H-1-NMR) spectroscopies. The swelling and thermal behavior of the obtained hydrogels indicates that the hydrogel starting from cholic acid is more swellable and has enhanced thermostability compared to others. Thus, the results of this study offer beneficial insights to researchers working in particularly bio-medical industry.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Unit [TUBAP 2018/92]en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Unit, Grant/Award Number: TUBAP 2018/92en_US
dc.identifier.doi10.1002/pat.5077
dc.identifier.endpage227en_US
dc.identifier.issn1042-7147
dc.identifier.issn1099-1581
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85090219443en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage220en_US
dc.identifier.urihttps://doi.org/10.1002/pat.5077
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19075
dc.identifier.volume32en_US
dc.identifier.wosWOS:000566451400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPolymers For Advanced Technologiesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBile Aciden_US
dc.subjectHydrogelen_US
dc.subjectSwelling Behavioren_US
dc.subjectThermal Propertiesen_US
dc.subjectCholic-Aciden_US
dc.subjectBlock-Copolymersen_US
dc.subjectDrug-Deliveryen_US
dc.subjectPolymerizationen_US
dc.subjectFooden_US
dc.subjectCombinationen_US
dc.subjectCompositesen_US
dc.subjectNetworksen_US
dc.titleSynthesis of new bio-based hydrogels derived from bile acids by free-radical photo-polymerizationen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu