Frequent oral ulceration during early disease may predict a severe disease course in males with Behçet's syndrome
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The numbers and recurrence rates of mucocutaneous manifestations can be highly variable among patients with Behçet's syndrome (BS) but it is not known whether these differences influence the disease course at the long-term. Methods: We evaluated the outcome of 30 patients that made up the placebo arm of a 6 months controlled trial of thalidomide and looked at the relation between the frequencies of mucocutaneous manifestations during the trial and the development of major organ involvement necessitating immunosuppressives during the post-trial period. Results: Fifteen (50%) patients had received immunosuppresives for major organ involvement during the post-trial period. Patients receiving immunosuppressive treatment were significantly younger at the onset of BS compared to those who did not (24.5±5 vs. 29.7±3.8 SD years; p=0.003). The mean number of oral ulcers recorded throughout the trial was significantly higher among patients using immunosuppressives compared to those who did not (2.09±0.96 vs. 1.43±0.8; p=0.029). This significance disappeared when adjusted for age of onset of BS (p=0.16). ROC curve analysis showed that having 10 or more ulcers during 6 months has a sensitivity of 86.7% and a specificity of 53% for the subsequent necessity of immunosuppressive use. The same association was not true for genital ulcers, follicular lesions and erythema nodosum. Conclusion: These findings on a limited number of patients suggest that frequent occurrence of oral ulceration during the initial years of the disease may predict the development of major organ involvement in men with BS. © Clinical and Experimental Rheumatology 2012.
Açıklama
Anahtar Kelimeler
Behçet's Disease; Major Organ Involvement; Oral Ulcers; Outcome; Prognosis, Placebo; Thalidomide; Immunosuppressive Agent; Thalidomide; Adult; Article; Behcet Disease; Clinical Article; Clinical Assessment; Controlled Study; Disease Severity; Drug Efficacy; Drug Induced Disease; Erythema Nodosum; Follicular Lesion; Genital Ulcer; Human; Immunosuppressive Treatment; Male; Mouth Ulcer; Onset Age; Prediction; Priority Journal; Receiver Operating Characteristic; Recurrent Disease; Risk Factor; Sensitivity And Specificity; Treatment Response; Adolescent; Age; Behcet Disease; Chi Square Distribution; Controlled Clinical Trial; Disease Course; Mouth Ulcer; Prognosis; Risk Assessment; Severity Of Illness Index; Sex Difference; Time; Turkey (Republic); Adolescent; Adult; Age Factors; Behcet Syndrome; Chi-Square Distribution; Disease Progression; Humans; Immunosuppressive Agents; Male; Oral Ulcer; Prognosis; Recurrence; Risk Assessment; Risk Factors; Roc Curve; Severity Of Illness Index; Sex Factors; Thalidomide; Time Factors; Turkey; Young Adult
Kaynak
Clinical and Experimental Rheumatology
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
30
Sayı
SUPPL.72
