Assessing the correlation between FDG PET findings of IDC breast carcinoma and histopathology of coexisting ductal carcinoma in-situ

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dc.authoridSarikaya, Ismet/0000-0002-1087-580X
dc.authorwosidSarikaya, Ismet/G-7881-2015
dc.contributor.authorSarikaya, Ismet
dc.contributor.authorSarikaya, Ali
dc.contributor.authorAlbatineh, Ahmed N.
dc.contributor.authorTastekin, Ebru
dc.contributor.authorSezer, Yavuz Atakan
dc.date.accessioned2024-06-12T10:55:15Z
dc.date.available2024-06-12T10:55:15Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Ductal carcinoma in-situ (DCIS) often coexists with invasive ductal carcinoma (IDC) of the breast. DCIS is consid-ered as a non-obligate precursor of IDC when both coexist. F-18-fluorodeoxyglucose positron emission tomography/computed tomography ([F-18]FDG PET/CT) imaging is commonly used in the staging and follow-up assessment of breast cancer. In this study, we aimed to assess if there is any correlation between primary tumor PET and histopathology findings and histopatho-logical features of the coexisting DCIS. Material and methods: FDG PET/CT images and histopathology results of the patients with newly diagnosed breast cancer (IDC) with coexisting DCIS were analyzed in this retrospective study. The grade and size of the primary tumor and histopathological features of the coexisting DCIS (nuclear grade and architectural pattern) were obtained from the postoperative histopathology results. Maximum standardized uptake values (SUV: SUVmax and SULmax) of the primary tumor normalized by weight and lean body mass were measured. Statistical analysis was performed to assess the correlation between various parameters of IDC and DCIS. Results: This study included sixty-two (62) patients with IDC-DCIS. Primary tumor grade was significantly correlated and associated with the nuclear grade of the coexisting DCIS (polychoric correlation r = 0.736, and Fisher exact test, PV < 0.001, respectively). Primary tumor SUV was not correlated with the nuclear grade and architectural pattern of the coexisting DCIS (polyserial correlation r = 0.172, PV = 0.155, and Point Bi-Serial correlation r = -0.009, PV = 0.955, respectively). Median primary tumor size was marginally significantly different among DCIS nuclear grades but it was not significantly different in comedo and non-comedo cases (Kruskal-Wallis test PV = 0.053, and Mann-Whitney U test PV = 0.890, respectively). Conclusions: Primary tumor grade is correlated with the nuclear grade of the coexisting DCIS. SUV of primary tumor does not seem to be correlated with the histopathological features of coexisting DCIS (nuclear grade and architectural pattern) but this may be further studied in a larger number of patients.en_US
dc.identifier.doi10.5603/NMR.a2022.0003
dc.identifier.endpage11en_US
dc.identifier.issn1506-9680
dc.identifier.issn1644-4345
dc.identifier.issue1en_US
dc.identifier.pmid35137931en_US
dc.identifier.scopus2-s2.0-85124319757en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage6en_US
dc.identifier.urihttps://doi.org/10.5603/NMR.a2022.0003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19358
dc.identifier.volume25en_US
dc.identifier.wosWOS:000754076200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofNuclear Medicine Reviewen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast Carcinomaen_US
dc.subjectInvasive Ductal Carcinomaen_US
dc.subjectCoexisting DCISen_US
dc.subjectFDG PETen_US
dc.subjectNuclear Gradeen_US
dc.subjectArchitectural Patternen_US
dc.subjectCanceren_US
dc.subjectDcisen_US
dc.subjectProgressionen_US
dc.subjectExpressionen_US
dc.subjectDiseaseen_US
dc.subjectAggressivenessen_US
dc.subjectParametersen_US
dc.subjectComponenten_US
dc.subjectPren_US
dc.subjectEren_US
dc.titleAssessing the correlation between FDG PET findings of IDC breast carcinoma and histopathology of coexisting ductal carcinoma in-situen_US
dc.typeArticleen_US

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