Tiroit fonksiyon bozukluğu olan hastalarda arerojenite indeksinin değerlendirilmesi
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Trakya Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Tiroit hastalıkları metabolizma üzerinde büyük etkileri olan, toplumda en sık görülen kronik hastalıklardan biridir. Dislipidemi ve tiroit hastalıkları arasında da belirgin bir ilişki vardır. Plazma aterojenite indeksi bu değerlendirmede kullanılabilen göstergelerden biri olarak kabul edilmeye başlanmıştır. Çalışmamız, tiroit fonksiyon bozukluğu olan hastaların plazma aterojenite indekslerini hesaplayarak, bu hastalık grubundaki farklılıkları ortaya koymayı hedeflemektedir. Trakya Üniversitesi Tıp Fakültesi hastanesi genel dahiliye polikliniğine, 01/06/2020- 31/12/2020 tarihleri arasında başvuran dahil edilme özelliklerini taşıyan 372 hasta değerlendirilmiş ve hastaların plazma aterojenite indeksi hesaplanmıştır. Çalışmamızda tiroit fonksiyon bozukluğu olan hastalarda olmayanlara göre plazma aterojenite indeksi istatistiksel olarak anlamlı (p<0,001) bulunmuştur. Alt gruplara bakıldığında özellikle hipotiroidisi olan hastaların plazma aterojenite indeksi değerlerinin anlamlı (p<0,001) oranda yüksek olduğu görülmüştür. ROC analizinde plazma aterojenite indeksi için cut-off değeri >0,45 (yüksek risk) olarak saptanmış, %53 sensitivite ve %93 spesifite olarak değerlendirilmiştir. Bu iki grup arasında yapılan analizlerde yüksek riskli hasta grupta anlamlı olarak tiroit fonksiyon bozukluğu olan hastalar daha fazla olarak görüldü (p<0,001). Üç farklı model üzerinden çok değişkenli ikili lojistik regresyon analizleri yapılıp sonucunda tiroid fonksiyon bozukluğu, diyabetes mellitus, vücut kitle indeksi, kolesterol ve düşük yoğunluklu lipoprotein, yüksek riskli hastaları ön gördürmede bağımsız değişkenler olarak karşımıza çıkmıştır. Sonuç olarak tiroit fonksiyon bozukluğu olan hastalarda plazma aterojenite indeksinin yol gösterici bir parametre olduğunu saptadık. Birinci basamak sağlık hizmetlerinde kolaylıkla uygulanabilecek bu parametrenin aterosklerotik riski ön görmede ve hastaların tedavilerine yol göstermede kullanılabileceğini; ayrıca daha geniş ve kapsamlı çalışmalarla tiroit fonksiyon bozukluğu ile plazma aterojenite indeksi arasındaki anlamlı ilişkinin daha net kanıtlarla desteklenebileceğini düşünmekteyiz. Anahtar Kelimeler: Plazmanın aterojenik indeksi, lipid profili, dislipidemi, hipotiroidizm, tiroit fonksiyon bozukluğu
Thyroid diseases are one of the most common chronic diseases in the population with a major impact on metabolism. There is also a meaningful relationship between dyslipidemia and thyroid diseases. The plasma atherogenicity index has started to be accepted as one of the indicators that can be used in this evaluation. Our study aims to calculate the plasma atherogenicity index of patients with thyroid dysfunction and to reveal the differences in this disease group. 372 patients with inclusion criteria who applied to the general internal medicine outpatient clinic of Trakya University Faculty of Medicine Hospital between 01/06/2020 and 31/12/2020 were evaluated and plasma atherogenicity index was calculated. In our study, plasma atherogenicity index was found to be statistically significant (p<0.001) in patients with thyroid dysfunction compared to those without it. When subgroups were analyzed, it was observed that plasma atherogenicity index values were significantly (p<0.001) higher in patients with hypothyroidism. In the ROC analysis, the cut-off value for the plasma atherogenicity index was determined as >0.45 (high risk) with 53% sensitivity and 93% specificity. In the analysis between these two groups, patients with thyroid dysfunction were significantly higher in the high-risk patient group (p<0.001). Multivariate binary logistic regression analyses were performed on three different models and as a result, thyroid dysfunction, diabetes mellitus, body mass index, cholesterol, and low-density lipoprotein were detected as independent variables in predicting high-risk patients. In conclusion, we found that plasma atherogenicity index is a guiding parameter in patients with thyroid dysfunction. We think that this parameter, which can be easily applied in primary health care services, can be used to predict atherosclerotic risk, and guide the treatment of patients; we also think that the significant relationship between thyroid dysfunction and plasma atherogenicity index can be supported with more apparent evidence with more extensive and comprehensive studies. Keywords: Atherogenic index of plasma, lipid profile, dyslipidemia, hypothyroidism, thyroid dysfunction
Thyroid diseases are one of the most common chronic diseases in the population with a major impact on metabolism. There is also a meaningful relationship between dyslipidemia and thyroid diseases. The plasma atherogenicity index has started to be accepted as one of the indicators that can be used in this evaluation. Our study aims to calculate the plasma atherogenicity index of patients with thyroid dysfunction and to reveal the differences in this disease group. 372 patients with inclusion criteria who applied to the general internal medicine outpatient clinic of Trakya University Faculty of Medicine Hospital between 01/06/2020 and 31/12/2020 were evaluated and plasma atherogenicity index was calculated. In our study, plasma atherogenicity index was found to be statistically significant (p<0.001) in patients with thyroid dysfunction compared to those without it. When subgroups were analyzed, it was observed that plasma atherogenicity index values were significantly (p<0.001) higher in patients with hypothyroidism. In the ROC analysis, the cut-off value for the plasma atherogenicity index was determined as >0.45 (high risk) with 53% sensitivity and 93% specificity. In the analysis between these two groups, patients with thyroid dysfunction were significantly higher in the high-risk patient group (p<0.001). Multivariate binary logistic regression analyses were performed on three different models and as a result, thyroid dysfunction, diabetes mellitus, body mass index, cholesterol, and low-density lipoprotein were detected as independent variables in predicting high-risk patients. In conclusion, we found that plasma atherogenicity index is a guiding parameter in patients with thyroid dysfunction. We think that this parameter, which can be easily applied in primary health care services, can be used to predict atherosclerotic risk, and guide the treatment of patients; we also think that the significant relationship between thyroid dysfunction and plasma atherogenicity index can be supported with more apparent evidence with more extensive and comprehensive studies. Keywords: Atherogenic index of plasma, lipid profile, dyslipidemia, hypothyroidism, thyroid dysfunction
Açıklama
Tıpta Uzmanlık
Anahtar Kelimeler
Aile Hekimliği, Family Medicine
