Appreciation of trimetazidine treatment in experimental sepsis rat model
Küçük Resim Yok
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Comenius Univ
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: Our aim was to determine the efficacy of trimetazidine on experimental sepsis rat model. Material and methods: Sixty rats were randomized into three groups. In Group 1, sepsis was induced. In Group 2, sepsis was induced and as a therapeutic agent trimetazidine was given. In Group 3, rats were sham operated. Serum interleukin-1 beta (IL-1 beta), tumor necrosis factor alfa (TNF-alpha), superoxide dismutase (SOD), glutathion peroxidase (GSH-Px) and malondialdehyde (MDA) levels were determined in all groups. Results: In Group 2, serum GSH-Px and SOD levels were statistically significantly higher than in Group 1 (p < 0.05) and serum MDA levels were statistically significantly lower than in group 1 (p < 0.05). Trimetazidine also significantly decreased the levels of IL-1 beta and TNF-alpha which are the proinflammatory cytokines (p < 0.05). Conclusion: Trimetazidine treatment significantly improved inflammation, oxidative stress and membrane destruction in LPS-induced sepsis. As the proinflammatory cytokines are supposed to play a primary role in the pathogenesis of sepsis, we assumed that the trimetazidine treatment would give new insights into the treatment of sepsis (Tab. 1, Fig. 5, Ref. 29). Text in PDF www.elis.sk.
Açıklama
Anahtar Kelimeler
Sepsis, Trimetazidine, Inflammation, Proinflammatory Cytokines, Oxygen-Free-Radicals, Lipid-Peroxidation, Septic Shock, Survival
Kaynak
Bratislava Medical Journal-Bratislavske Lekarske Listy
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
116
Sayı
2
