The influence of N-acetyl-L-cystein infusion on cytokine levels and gastric intramucosal pH during severe sepsis

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dc.contributor.authorEmet, S
dc.contributor.authorMemis, D
dc.contributor.authorPamukçu, Z
dc.date.accessioned2024-06-12T10:59:07Z
dc.date.available2024-06-12T10:59:07Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction The purpose of the present study was to evaluate the effects of continuously infused N-acetyl-L-cystein (NAC) on serum cytokine levels and gastric intramucosal pH in humans suffering from severe sepsis. Methods Fifty-three patients were included in the study. In the NAC group (n = 27), after an initial intravenous bolus of NAC (150 mg/kg over 5 min), a continuous intravenous infusion of 12.5 mg/kg per hour was given for 6 hours. Patients in the control group (n = 26) were administered dextrose (5% solution) at the same dosage. We recorded the following: haemodynamic parameters, nasopharyngeal temperature, arterial blood gas changes, plasma cytokine levels, biochemical parameters, intramucosal pH, length of stay in the intensive care unit, duration of of mechanical ventilation and mortality. All measurements were taken at baseline (15 min before the start of the study) and were repeated immediately after the bolus infusion, and at 24 and 48 hours after initiation of the continuous NAC infusion. Results No differences were found between groups in levels of the major cytokines, duration of ventilation and intensive care unit stay, gastric intramucosal pH and arterial oxygen tension/inspired fractional oxygen ratio (P > 0.05). Conclusion We found that NAC infusion at the doses given did not affect cytokine levels, outcomes, or gastric intramucosal pH in patients with severe sepsis. Because of the limited number of patients included in the study and the short period of observation, our findings need confirmation in larger clinical trials of NAC infused in a dose-titrated manner. However, our results do not support the use of NAC in patients with severe sepsis.en_US
dc.identifier.doi10.1186/cc2866
dc.identifier.endpageR179en_US
dc.identifier.issn1466-609X
dc.identifier.issn1364-8535
dc.identifier.issue4en_US
dc.identifier.pmid15312215en_US
dc.identifier.scopus2-s2.0-4344704439en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageR172en_US
dc.identifier.urihttps://doi.org/10.1186/cc2866
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20323
dc.identifier.volume8en_US
dc.identifier.wosWOS:000223304600003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBiomed Central Ltden_US
dc.relation.ispartofCritical Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytokine Levelsen_US
dc.subjectGastric Intramucosal Phen_US
dc.subjectHaemodynamic Parametersen_US
dc.subjectIntensive Care Uniten_US
dc.subjectN-Acetyl-L-Cysteinen_US
dc.subjectSevere Sepsisen_US
dc.subjectRespiratory-Distress-Syndromeen_US
dc.subjectFulminant Hepatic-Failureen_US
dc.subjectHuman Septic Shocken_US
dc.subjectDouble-Blinden_US
dc.subjectOrgan Dysfunctionen_US
dc.subjectAcetylcysteineen_US
dc.subjectTrialen_US
dc.subjectAntioxidantsen_US
dc.subjectGlutathioneen_US
dc.subjectActivationen_US
dc.titleThe influence of N-acetyl-L-cystein infusion on cytokine levels and gastric intramucosal pH during severe sepsisen_US
dc.typeArticleen_US

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