Congenital and perinatal cytomegalovirus infections in the neonatal period: Case series
Küçük Resim Yok
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
AVES
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Cytomegalovirus infection when diagnosed in the first three weeks of life is generally accepted to be indicative of a “congenital” or “vertical” infection, whereas when cytomegalovirus infection is diagnosed after the first three weeks of life, it is generally considered as “peri-natal” or “horizontal” infection. Since diagnosis of either a congenital or perinatal cytomegalovirus infection is challenging, as well as their treat-ment, this study aimed to address the issues about the diagnosis and treatment of congenital/perinatal cytomegalovirus infection by present-ing a series of infants followed-up in our neonatal intensive care unit. Material and Methods: Medical records of newborn infants with con-genital/perinatal cytomegalovirus infection who were admitted to our level III neonatal intensive care unit between August 2015 and May 2018 were evaluated retrospectively. Only infants who received cytomegalo-virus-specific therapy were included. Results: Out of 1039 infants admitted to the neonatal intensive care unit during the study period, 8 (0.8%) were diagnosed and treated for con-genital/perinatal cytomegalovirus infections. All of them were preterm infants. Four infants found to be CMV positive during the first 21 days of life were diagnosed as congenital cytomegalovirus infection, while a perinatal and congenital infection differentiation could not be made in the rest of the patients. Anemia (75%), thrombocytopenia (62.5%) and hearing loss (62.5%) were the most common findings in patients with congenital/perinatal infection. None of the infants had chorioretinitis. Two infants (25%) with microcephaly had intracranial calcifications. Sep-sis-like findings were present in three very preterm infants (37.5%). Cyto-megalovirus-IgM was positive in all 8 infants with infection; however, se-rum CMV-DNA was positive in seven of them. All infants with moderate to severe symptoms were treated with ganciclovir and/or valganciclovir. Viral load decreased dramatically at the end of the treatment period. Conclusion: Cytomegalovirus infection, either congenital or perinatal, is a greater risk especially for preterm infants who may warrant and benefit from newborn cytomegalovirus screening, early detection, and effective antiviral treatment. © 2020 by Pediatric Infectious Diseases and Immunization Society.
Açıklama
Anahtar Kelimeler
Congenital Infection; Cytomegalovirus; Newborn; Perinatal Infection; Preterm, Ganciclovir; Valganciclovir; Virus Dna; Antiviral Therapy; Article; Blood Transfusion; Brain Calcification; Chorioretinitis; Clinical Article; Congenital Infection; Cytomegalovirus Infection; Enzyme Linked Immunosorbent Assay; Follow Up; Gene Dosage; Gestational Age; Hearing Impairment; Hearing Test; Human; Infection Risk; Liver Function Test; Microcephaly; Neonatal Intensive Care Unit; Newborn; Newborn Period; Newborn Screening; Perinatal Infection; Real Time Polymerase Chain Reaction; Retrospective Study; Sepsis; Thrombocytopenia; Virus Load
Kaynak
Cocuk Enfeksiyon Dergisi
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
14
Sayı
1
