Protective effects of thymoquinone and methotrexate on the renal injury in collagen-induced arthritis

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dc.authoridUYSAL, HAMDI/0000-0002-2289-1815
dc.authorwosidDemirel, Adnan/GWC-0241-2022
dc.authorwosidUYSAL, HAMDI/AAF-9708-2020
dc.contributor.authorBudancamanak, Mustafa
dc.contributor.authorKanter, Mehmet
dc.contributor.authorDemirel, Adnan
dc.contributor.authorOcakci, Ayse
dc.contributor.authorUysal, Hamdi
dc.contributor.authorKarakaya, Cengiz
dc.date.accessioned2024-06-12T11:16:21Z
dc.date.available2024-06-12T11:16:21Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe goal of this investigation was to study the protective effects of thymoquinone (TQ) and methotrexate (MTX) on collagen-induced arthritis (CIA) in rats. On day 0 under ether anesthesia, the experimental groups were immunized with 0.5 mg native chick collagen II (CII) solubilized in 0.1 M acetic acid and emulsified in Freund's incomplete adjuvant. Control rats were gavaged with vehicle, whereas CII was administered intradermally. In addition, arthritis treated with TQ group received TQ (10 mg kg(-1) stop bw by gavage once a week for 3 weeks starting on day 0); and arthritis treated with MTX group received MTX (MTX was suspended in corn oil and administered by gavage at 1 mg kg(-1) stop bw once a week for 3 weeks starting on day 0). A significant decrease in the incidence and severity of arthritis by clinical and radiographic assessments was found in recipients of therapy, compared with that of controls. The MTX treatment significantly (P < 0.01) decreased the elevated serum NO, urea and creatinine in arthritic rats. Likewise, TQ treatment was also able to reduce significantly (P < 0.05) serum NO, urea and creatinine levels, but to lesser extent than MTX. The histopathologic abnormalities are consistent with the hydropic epithelial cell degenerations and moderate tubular dilatation in the some proximal and distal tubules. The severity of the degenerative changes in most of the shrunken glomerules and vascular congestion were also observed in arthritic animals. Preventive treatment of TQ and especially MTX significantly inhibited kidney dysfunction and this histopathologic alterations. These studies indicate that TQ can be used similar to MTX as a safe and effective therapy for CIA and may be useful in the treatment of rheumatoid arthritis.en_US
dc.identifier.doi10.1007/s00204-006-0094-0
dc.identifier.endpage776en_US
dc.identifier.issn0340-5761
dc.identifier.issn1432-0738
dc.identifier.issue11en_US
dc.identifier.pmid16609887en_US
dc.identifier.scopus2-s2.0-33751437702en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage768en_US
dc.identifier.urihttps://doi.org/10.1007/s00204-006-0094-0
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24287
dc.identifier.volume80en_US
dc.identifier.wosWOS:000242294800007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives Of Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThymoquinoneen_US
dc.subjectMethotrexateen_US
dc.subjectRenal Injuryen_US
dc.subjectCollagen-Induced Arthritisen_US
dc.subjectRaten_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectDoxorubicin-Induced Cardiotoxicityen_US
dc.subjectRheumatoid-Arthritisen_US
dc.subjectNigella-Sativaen_US
dc.subjectDouble-Blinden_US
dc.subjectAdjuvant Arthritisen_US
dc.subjectPulse Methotrexateen_US
dc.subjectVolatile Oilen_US
dc.subjectExpressionen_US
dc.subjectCyclosporineen_US
dc.titleProtective effects of thymoquinone and methotrexate on the renal injury in collagen-induced arthritisen_US
dc.typeArticleen_US

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