The effect of acute and chronic formaldehyde exposure on learning and memory in male and female rats

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dc.authoridErsoy, Onur/0000-0001-9829-7903
dc.authoridULUCAM, Enis/0000-0002-4686-7350
dc.authoriddonmez aydin, didem/0000-0002-9097-6634
dc.authorwosidErsoy, Onur/AAZ-5121-2020
dc.contributor.authorAydin, Didem Donmez
dc.contributor.authorTaskinalp, Oguz
dc.contributor.authorUlucam, Enis
dc.contributor.authorKaradag, Hakan
dc.contributor.authorOzfidan, Gulnur Kizilay
dc.contributor.authorTopuz, Ruhan
dc.contributor.authorErsoy, Onur
dc.date.accessioned2024-06-12T11:07:31Z
dc.date.available2024-06-12T11:07:31Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAimFormaldehyde is a chemical that lies behind the various systemical failures in organism. Many products that people use contain formaldehyde. Owing to its tissue fixative properties, scientists who work in life sciences are exposed to this substance more than others. Several studies have shown that formaldehyde affects the CA1 and CA3 regions of the hippocampus, which play crucial roles in memory consolidation. In this study, we aimed to investigate anxiety levels and indicate the short and long term effects of formaldehyde and sex-related differences by exposing formaldehyde to male and female rats.Materials and MethodsFormaldehyde (10 mg/kg) was administered intraperitoneally for 7 days for acute exposure and 30 days for chronic exposure. Cognitive assessment was performed using fear conditioning, elevated plus maze, and Morris water maze tests. TUNEL staining was used to identify apoptosis in the brains obtained after decapitation.ResultsExposure to intraperitoneal formaldehyde does not impair learning and memory in acute and chronic periods and has no effect on depression or anxiety. After acute exposure, apoptosis was observed in the hippocampal CA1 and CA3 regions in males. When the cognitive test results were examined, no differences were found between the experimental and control groups. There was also no significant difference between males and females.en_US
dc.description.sponsorshipTrakya University scientific Research Project Department (tUBaP) [2016/47]; Council of higher education (YOEK)en_US
dc.description.sponsorshipthis Project has supported by trakya University scientific Research Project Department (tUBaP) (2016/47) and council of higher education (YOEK)en_US
dc.identifier.doi10.1080/00207454.2023.2300728
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.pmid38152865en_US
dc.identifier.scopus2-s2.0-85181706928en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/00207454.2023.2300728
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22080
dc.identifier.wosWOS:001138465700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLearning And Memoryen_US
dc.subjectFormaldehydeen_US
dc.subjectMorris Water Mazeen_US
dc.subjectFear Conditioningen_US
dc.subjectPlus Mazeen_US
dc.subjectHippocampusen_US
dc.subjectMorris Water Mazeen_US
dc.subjectSpatial Memoryen_US
dc.subjectOxidative Damageen_US
dc.subjectMap Formationen_US
dc.subjectHippocampusen_US
dc.subjectNeurotoxicityen_US
dc.subjectImpairmenten_US
dc.subjectCortexen_US
dc.titleThe effect of acute and chronic formaldehyde exposure on learning and memory in male and female ratsen_US
dc.typeArticleen_US

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