Protective Effect of Curcumin Against Gentamicin-induced Nephrotoxicity Mediated by p38 MAPK, Nuclear Factor-Kappa B, Nuclear Factor Erythroid 2-Related Factor 2

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dc.authoridUz, Yesim/0000-0002-0381-4590
dc.contributor.authorUzun-Goren, Duygu
dc.contributor.authorUz, Yesim Hulya
dc.date.accessioned2024-06-12T10:58:58Z
dc.date.available2024-06-12T10:58:58Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction. The antioxidant activity of curcumin (CMN) has been evaluated in several studies. We aimed to examine the protective effect of curcumin on gentamicin-induced nephrotoxicity in rats, both at histological and immunohistochemical levels. Methods. Forty male Wistar albino rats were assigned into four groups of 10 as follows: group 1: control, group 2: curcumin for 15 days, group 3: gentamicin for the last 10 days, and group 4: curcumin for 15 days and gentamicin for the last 10 days. Curcumin (100 mg/kg/d) was gavaged, and gentamicin (80 mg/kg/d) was injected intraperitoneally. Kidney tissues and blood were collected for histological, immunohistochemical and biochemical studies. Body weight and kidney weight/body weight changes were recorded. Results. Gentamicin nephrotoxicity was characterized by a significant rise in serum urea and creatinine levels and a significant reduction in body weight and an increase in kidney weight/body weight. The gentamicin group showed degenerative changes in tubules and glomeruli together with, increased phosphorylated (p)-p38 mitogen-activated protein kinase (p38 MAPK) positive cells in immunohistochemical evaluation, increased immunoreactivity of nuclear factor-kappa B (NFkB), and decreased immunoreactivity of nuclear factor erythroid 2-related factor 2 (Nrf2). Curcumin diminished body weight loss caused by gentamicin administration but, did not change the kidney weight/body weight. Moreover, curcumin ameliorated the histological alterations and reduced the biochemical parameters. Additionaly, curcumin significantly decreased p-p38 MAPK positive cells and NFkB immunoreactivity, while significantly increasing Nrf2 immunoreactivity in the kidney tissue. Conclusion. We conclude that curcumin may attenuate gentamicininduced nephrotoxicity by supprresing the p38 MAPK and NFkB, and activating the Nrf2 signaling pathways.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Trakya University [TUBAP 2009/113]en_US
dc.description.sponsorshipThis study was supported by Scientific Research Projects Coordination Unit of Trakya University (TUBAP 2009/113).en_US
dc.identifier.doi10.52547/ijkd.6647
dc.identifier.endpage107en_US
dc.identifier.issn1735-8582
dc.identifier.issn1735-8604
dc.identifier.issue2en_US
dc.identifier.pmid35489078en_US
dc.identifier.scopus2-s2.0-85129152470en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage96en_US
dc.identifier.urihttps://doi.org/10.52547/ijkd.6647
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20268
dc.identifier.volume16en_US
dc.identifier.wosWOS:000796620900005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIranian Soc Nephrolgyen_US
dc.relation.ispartofIranian Journal Of Kidney Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCurcuminen_US
dc.subjectGentamicinen_US
dc.subjectNephrotoxicityen_US
dc.subjectNuclear Factor Erythroiden_US
dc.subject2-Related Factor 2en_US
dc.subjectNuclearen_US
dc.subjectFactor-Kappa Ben_US
dc.subjectP38 Mitogen-Activated Protein Kinasesen_US
dc.subjectActivated Protein-Kinaseen_US
dc.subjectOxidative Stressen_US
dc.subjectKidneyen_US
dc.subjectInflammationen_US
dc.subjectExtracten_US
dc.subjectApoptosisen_US
dc.subjectInjuryen_US
dc.subjectToxicityen_US
dc.subjectNecrosisen_US
dc.subjectDamageen_US
dc.titleProtective Effect of Curcumin Against Gentamicin-induced Nephrotoxicity Mediated by p38 MAPK, Nuclear Factor-Kappa B, Nuclear Factor Erythroid 2-Related Factor 2en_US
dc.typeArticleen_US

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