Tissue factor pathway inhibitor and thrombin-activatable carboxypeptidase B for prediction of early atherosclerosis in gouty arthritis

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dc.authoridUyanik, Mehmet/0000-0001-7359-387X
dc.authorwosidUyanik, Mehmet/AAD-7345-2020
dc.contributor.authorUyanik, Mehmet Sevki
dc.contributor.authorPamuk, Gulsum Emel
dc.contributor.authorPamuk, Omer Nuri
dc.contributor.authorTuncel, Sedat Alpaslan
dc.date.accessioned2024-06-12T11:02:48Z
dc.date.available2024-06-12T11:02:48Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Gouty arthritis (GA) is a chronic inflammatory arthritis in which both clinical and subclinical atherosclerosis are more frequent. The dynamic equilibrium between coagulation and fibrinolysis is impaired in inflammatory diseases. We determined TFPI and TAFI antigen levels in GA patients and evaluated their association with subclinical atherosclerosis. Methods: We included 45 GA patients (41 males, 4 females; mean age: 51.6 years) and 25 asymptomatic hyperuricemic (AHU) subjects (19 males, 6 females; mean age: 48.1 years). Cardiovascular risk factors were determined. TAFI and TFPI levels were determined by ELISA. B-mode ultrasonography was used to detect subclinical atherosclerosis. Results: Cardiovascular risk factors were similar in both groups. The carotid IMT was significantly higher in GA group than in AHU group (0.74 +/- 0.23 mm vs. 0.61 +/- 0.13 mm, p = 0.009). TFPI level was significantly higher in GA group than in AHU group (86.2 +/- 48.9 ng/mL vs. 25.8 +/- 21.4 ng/mL, p < 0.001); TAFI antigen was significantly higher in AHU group (22.6 +/- 3.6 ng/mL vs. 25.7 +/- 5.3 ng/mL, p = 0.006) than in GA patients. Atherosclerotic plaque formation was more frequent in GA group (p = 0.041). When GA patients with and without plaques were compared, the first group had significantly higher mean age (p = 0.01) and TFPI level (p = 0.028). TFPI level correlated with carotid IMT (r = 0.302; p = 0.028). Logistic regression analysis showed that age (OR: 1.236, 95%CI: 1.059-1.443, p = 0.007) and TFPI (OR: 1.031, 95%CI: 1.008-1.054, p = 0.008) were independent risk factors for the presence of plaques. Conclusions: GA patients had more frequent subclinical atherosclerosis than subjects with AHU. Higher TFPI levels in GA patients -probably associated with enhanced endothelial damage-were related to subclinical atherosclerosis. Lower TAFI levels in GA pointed to impaired fibrinolysis. (C) 2014 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.thromres.2014.06.006
dc.identifier.endpage530en_US
dc.identifier.issn0049-3848
dc.identifier.issn1879-2472
dc.identifier.issue2en_US
dc.identifier.pmid24974054en_US
dc.identifier.scopus2-s2.0-84905104949en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage526en_US
dc.identifier.urihttps://doi.org/10.1016/j.thromres.2014.06.006
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21407
dc.identifier.volume134en_US
dc.identifier.wosWOS:000341309200050en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofThrombosis Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGouty Arthritisen_US
dc.subjectAtherosclerosisen_US
dc.subjectFibrinolytic Systemen_US
dc.subjectThrombin-Activatable Carboxypeptidase B (TAFI)en_US
dc.subjectTissue Factor Pathway Inhibitor (TFPI)en_US
dc.subjectRheumatoid-Arthritisen_US
dc.subjectPlasminogen-Activatoren_US
dc.subjectUric-Aciden_US
dc.subjectPlasmaen_US
dc.subjectRisken_US
dc.subjectFibrinolysisen_US
dc.subjectInflammationen_US
dc.subjectCoagulationen_US
dc.subjectDiseaseen_US
dc.subjectShortensen_US
dc.titleTissue factor pathway inhibitor and thrombin-activatable carboxypeptidase B for prediction of early atherosclerosis in gouty arthritisen_US
dc.typeArticleen_US

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