Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture

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dc.authoridCINAR, Irfan/0000-0002-9826-2556
dc.authoridBinnetoglu, Damla/0000-0002-7041-7253
dc.authoridYayla, Muhammed/0000-0002-0659-3084
dc.authoridDemirbag, Caglar/0000-0001-7534-341X
dc.authorwosidCINAR, Irfan/HPI-1003-2023
dc.authorwosidDemirbağ, Çağlar/KII-5788-2024
dc.contributor.authorCinar, Irfan
dc.contributor.authorYayla, Muhammed
dc.contributor.authorDemirbag, Caglar
dc.contributor.authorBinnetoglu, Damla
dc.date.accessioned2024-06-12T11:12:36Z
dc.date.available2024-06-12T11:12:36Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Cancer is the most common cause of death after cardiovascular diseases. Cisplatin used in most types of cancer produces neurotoxicity. In this study, we aimed to investigate the effects of pomegranate peel extract (1) in different doses, as potent antioxidants, on the prevention of neurotoxicity due to cisplatin, which is frequently used in cancer treatment. Methods: In our study, newborn rat cortex was used. 2 hours following the application of PPE at 200, 300 and 400 mg/mL, neurotoxicity was established by applying cisplatin in 50 and 100 mu M concentrations. Results: In our study, cisplatin decreased cell viability in increasing doses, while PPE showed the best neuroprotective effect in high doses. Increased total oxidant capacity due to toxicity was significantly improved by PPE4. The antioxidant capacity decreased in the toxicity group showed improvement with the administration of PPE4. At the same time, increased TNF-alpha mRNA expression after cisplatin administration was significantly reduced with the administration of PPE4. The increased caspase 3 (CAS 3) and caspase 9 (CAS 9) mRNA expression due to cisplatin showed improvement with the administration of PPE4. Conclusion: These results indicated that PPE could inhibit cisplatin-induced neurotoxicity, and these effects may be related to anti-apoptotic and antioxidants activities.en_US
dc.identifier.doi10.33808/clinexphealthsci.797718
dc.identifier.endpage64en_US
dc.identifier.issn2459-1459
dc.identifier.issue1en_US
dc.identifier.startpage59en_US
dc.identifier.trdizinid480229en_US
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci.797718
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/480229
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23239
dc.identifier.volume11en_US
dc.identifier.wosWOS:000636479400010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univ, Inst Health Sciencesen_US
dc.relation.ispartofClinical And Experimental Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPomegranateen_US
dc.subjectAntioxidanten_US
dc.subjectCisplatinen_US
dc.subjectNeurotoxicityen_US
dc.subjectPrimary Neuronen_US
dc.subjectNf-Kappa-Ben_US
dc.subjectIn-Vitroen_US
dc.titlePomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Cultureen_US
dc.typeArticleen_US

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